Trial reportBMC ophthalmology2015
Intra-observer and inter-observer repeatability of ocular surface interferometer in measuring lipid layer thickness.
Trial report in BMC ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Advances in Dry Eye Disease Examination Techniques.Frontiers in medicine · 2021Pooled it
- Dry eye disease due to meibomian gland dysfunction treated with Pinggan Yuyin Qingre formula: a stratified randomized controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Trial
- The influence of a mineral oil cationic nanoemulsion or perfluorohexyloctane on the tear film lipid layer and higher order aberrations.PloS one · 2023Trial
- The correlation between Demodex infestation and meibomian gland dysfunction at different ages.BMC ophthalmology · 2022Trial
- Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm.Scientific reports · 2018Trial
- Clinical Trial of Thermal Pulsation (LipiFlow) in Meibomian Gland Dysfunction With Preteatment Meibography.Eye & contact lens · 2016Trial
- An Eyelid Warming Device for the Management of Meibomian Gland Dysfunction.Journal of optometryTrial
- Repeatability and Reproducibility of the Dry Eye Analyzer in Participants With and Without Symptoms of Dry Eye.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Evaluating Dry Eye Disease Subtypes Based on Whole-Area Lipid Layer Thickness Assessment.Journal of clinical medicine · 2026Article
- Qualitative analysis and clinical implications of lipid layer thickness variability: A retrospective, cross-sectional study.PloS one · 2026Article
- Development and validation of a risk prediction model for dry eye disease in myopic children.Frontiers in medicine · 2026Article
- A Randomised Pilot Trial to Demonstrate the Feasibility of a Prototype Electronic Heating Device in Patients with Meibomian Gland Dysfunction.Biomedicines · 2025Article
- Repeatability of lipid layer thickness using LipiView® following removal of contact lenses and its relationship to comfort.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Categorization of Meibomian Gland Dysfunction Using Lipid Layer Thickness and Meibomian Gland Dropout in Dry Eye Patients: A Retrospective Study.Korean journal of ophthalmology : KJO · 2024Article
- Repeatability, reproducibility and agreement between three different diagnostic imaging platforms for tear film evaluation of normal and dry eye disease.Eye (London, England) · 2023Article
- Promising High-Tech Devices in Dry Eye Disease Diagnosis.Life (Basel, Switzerland) · 2023Review
- Lacrimal and meibomian gland evaluation in dry eye disease: A mini-review.Indian journal of ophthalmology · 2023Review
- The effect of incomplete blinking rate on corneal epithelial remodeling after trans-PRK surgery: a six-month study.Frontiers in medicine · 2023Article
- Dry eye disease and tear film assessment through a novel non-invasive ocular surface analyzer: The OSA protocol.Frontiers in medicine · 2022Article
- Meibomian gland atrophy with duration of Sjogren's syndrome in adult females.International ophthalmology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTear lipid morphology is important for normal tear function. Recently, there have been clinical studies using interferometry to assess lipid layer thickness (LLT). The aim of the study is to examine the repeatability of a commercially available interferometer.
methodsTwo observers measured LLT in twenty Asian subjects (20 eyes) using an interferometer (LipiView® ocular surface interferometer, TearScience Inc, Morrisville, NC). Dry eye symptoms, tear break up time (TBUT) and corneal fluorescein staining were also prospectively evaluated.
resultsData for 20 participants are presented for either right or left eye (randomly selected). The mean LLT ± standard deviation of these participants was 53.53 ± 14.59 nm. When a single observer repeated the imaging on the same day, the coefficient of repeatability was 16 nm and the 95% limits of agreement were between -11 nm and 18 nm. When a different observer repeated the scan, the coefficient of repeatability was 13 nm and limits of agreement were -9 nm and 16 nm. LLT was not significantly associated with TBUT, presence of any corneal staining in any corneal zones, or symptomatic status.
conclusionWith the repeatability of measurements being known, the significance of LLT changes measured by this interferometer may be better interpreted. In this small Asian study, the LLT was lower than previously reported studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.