ReviewChromosoma2016
LINEs in mice: features, families, and potential roles in early development.
Review in Chromosoma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Transcriptional perturbation of LINE-1 elements reveals their cis-regulatory potential.EMBO reports · 2026Article
- Reactivation of retrotransposable elements is associated with environmental stress and ageing.Nature reviews. Genetics · 2025Review
- HELQ Maintains Genome Stability of Primordial Germ Cells by Inhibiting LINE-1 Expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Core factor of NEXT complex, ZCCHC8, governs the silencing of LINE1 during spermatogenesis.National science review · 2025Article
- Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.PLoS genetics · 2024Article
- Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo.EMBO reports · 2024Review
- The discovery of multiple active mys-related LTR-retroelements within the Neotominae subfamily of cricetid rodents.Genetica · 2023Article
- Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elements.Cell genomics · 2023Article
- SoloTE for improved analysis of transposable elements in single-cell RNA-Seq data using locus-specific expression.Communications biology · 2022Article
- Sequestration of LINE-1 in cytosolic aggregates by MOV10 restricts retrotransposition.EMBO reports · 2022Article
- Control of LINE-1 Expression Maintains Genome Integrity in Germline and Early Embryo Development.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Spatially Resolved Expression of Transposable Elements in Disease and Somatic Tissue with SpatialTE.International journal of molecular sciences · 2021Article
- Analysis of LINE1 Retrotransposons in Huntington's Disease.Frontiers in cellular neuroscience · 2021Article
- Subfamily-specific quantification of endogenous mouse L1 retrotransposons by droplet digital PCR.Analytical biochemistry · 2020Article
- Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity.Nature communications · 2020Article
- Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells.Nucleic acids research · 2017Article
- Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations.Nature communications · 2017Article
- The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts.International journal of molecular sciences · 2017Review
- Small chromosomal regions position themselves autonomously according to their chromatin class.Genome research · 2017Article
- Exploratory bioinformatics investigation reveals importance of "junk" DNA in early embryo development.BMC genomics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately half of the mammalian genome is composed of repetitive elements, including LINE-1 (L1) elements. Because of their potential ability to transpose and integrate into other regions of the genome, their activation represents a threat to genome stability. Molecular pathways have emerged to tightly regulate and repress their transcriptional activity, including DNA methylation, histone modifications, and RNA pathways. It has become evident that Line-L1 elements are evolutionary diverse and dedicated repression pathways have been recently uncovered that discriminate between evolutionary old and young elements, with RNA-directed silencing mechanisms playing a prominent role. During periods of epigenetic reprogramming in development, specific classes of repetitive elements are upregulated, presumably due to the loss of most heterochromatic marks in this process. While we have learnt a lot on the molecular mechanisms that regulate Line-L1 expression over the last years, it is still unclear whether reactivation of Line-L1 after fertilization serves a functional purpose or it is a simple side effect of reprogramming.
Indexed as
Identifiers
25975894What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.