Evidence map›Paper›PMID 25975840›Full record

ArticleHaematologica2015

Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation.

Carine Fillebeen, Konstantinos Gkouvatsos, Gabriela Fragoso, Annie Calvé, Daniel Garcia-Santos, Marzell Buffler, Christiane Becker, Klaus Schümann, Prem Ponka, Manuela M Santos and 1 more

Open access · goldAbstract readLetter
In one paragraph

Article in Haematologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. International journal of molecular sciences · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Mechanisms controlling cellular and systemic iron homeostasis.Nature reviews. Molecular cell biology · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Molecular Mechanisms of Iron and Heme Metabolism.Annual review of nutrition · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Carine FillebeenDepartment of Medicine, McGill University, and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
Konstantinos GkouvatsosDepartment of Medicine, McGill University, and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
Gabriela FragosoDépartement de Médecine, Université de Montréal, and Centre de Recherche du Centre Hospitalier de l'Université de Montŕeal (CRCHUM), Montreal, Quebec, Canada.
Annie CalvéDépartement de Médecine, Université de Montréal, and Centre de Recherche du Centre Hospitalier de l'Université de Montŕeal (CRCHUM), Montreal, Quebec, Canada.
Daniel Garcia-SantosDepartment of Physiology, McGill University, and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
Marzell BufflerScience Center Weihenstephan, Technical University Munich, Am Forum 5, Freising, Germany.
Christiane BeckerScience Center Weihenstephan, Technical University Munich, Am Forum 5, Freising, Germany.
Klaus SchümannScience Center Weihenstephan, Technical University Munich, Am Forum 5, Freising, Germany.
Prem PonkaDepartment of Physiology, McGill University, and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
Manuela M SantosDépartement de Médecine, Université de Montréal, and Centre de Recherche du Centre Hospitalier de l'Université de Montŕeal (CRCHUM), Montreal, Quebec, Canada.
Kostas PantopoulosDepartment of Medicine, McGill University, and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada kostas.pantopoulos@mcgill.ca.
Centre Hospitalier de l’Université de Montréal · CAMcGill University · CAJewish General Hospital · CA

Funding

Canadian Institutes of Health Research MOP-123246Canadian Institutes of Health Research MOP-86514
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsHemeHeme Oxygenase-1Intestinal AbsorptionIronMembrane ProteinsMiceMice, KnockoutHemeHeme Oxygenase-1Hmox1 protein, mouseIronMembrane Proteinsdietary heme iron assimilationhigh-heme dietintestinal Hmox1iron overloadmice

Identifiers

PMID25975840
PMCPMC4800685
OpenAlexW2189254605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.