Evidence map›Paper›PMID 25975801›Full record

ArticleCell transplantation2016

Bone Marrow-Derived Mesenchymal Stem Cells Improve Diabetic Neuropathy by Direct Modulation of Both Angiogenesis and Myelination in Peripheral Nerves.

Ji Woong Han, Dabin Choi, Min Young Lee, Yang Hoon Huh, Young-sup Yoon

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ji Woong HanDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Dabin Choi
Min Young Lee
Yang Hoon Huh
Young-sup Yoon
Emory University · USKorea Basic Science Institute · KR

Funding

Cell therapy for diabetic peripheral neurovascular complicationsDP3DK094346 · NIDDK · EMORY UNIVERSITY · PI CHENG, XIAODONG, YOON, YOUNG-SUP · 2011 to 2011
$6.1M
Effects of reprogrammed and engineered MSCs on diabetic complicationsDP3DK108245 · NIDDK · EMORY UNIVERSITY · PI YOON, YOUNG-SUP · 2015 to 2016
$2.6M
Stem Cell-based therapy for LymphedemaR01HL127759 · NHLBI · EMORY UNIVERSITY · PI YOON, YOUNG-SUP · 2015 to 2018
$1.6M
Cardiac Regeneration with Bioengineered Human Stem CellsR01HL129511 · NHLBI · EMORY UNIVERSITY · PI YOON, YOUNG-SUP · 2016 to 2019
$1.6M
NHLBI NIH HHS HHSN268201000043CNHLBI NIH HHS R01 HL127759NHLBI NIH HHS R01 HL129511NIDDK NIH HHS DP3 DK094346NIDDK NIH HHS DP3DK094346NIDDK NIH HHS DP3 DK108245
6 · The paper itself

Abstract

Recent evidence has suggested that diabetic neuropathy (DN) is pathophysiologically related to both impaired angiogenesis and a deficiency of neurotrophic factors in the nerves. It is widely known that vascular and neural growths are intimately associated. Mesenchymal stem cells (MSCs) promote angiogenesis in ischemic diseases and have neuroprotective effects, particularly on Schwann cells. Accordingly, we investigated whether DN could be improved by local transplantation of MSCs by augmenting angiogenesis and neural regeneration such as remyelination. In sciatic nerves of streptozotocin (STZ)-induced diabetic rats, motor and sensory nerve conduction velocities (NCVs) and capillary density were reduced, and axonal atrophy and demyelination were observed. After injection of bone marrow-derived MSCs (BM-MSCs) into hindlimb muscles, NCVs were restored to near-normal levels. Histological examination demonstrated that injected MSCs were preferentially and durably engrafted in the sciatic nerves, and a portion of the engrafted MSCs were distinctively localized close to vasa nervora of sciatic nerves. Furthermore, vasa nervora increased in density, and the ultrastructure of myelinated fibers in nerves was observed to be restored. Real-time RT-PCR experiments showed that gene expression of multiple factors involved in angiogenesis, neural function, and myelination were increased in the MSC-injected nerves. These findings suggest that MSC transplantation improved DN through direct peripheral nerve angiogenesis, neurotrophic effects, and restoration of myelination.

Indexed as

AnimalsBone MarrowCells, CulturedDiabetes Mellitus, ExperimentalDiabetic NeuropathiesMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMyelin SheathNeovascularization, PathologicNerve RegenerationRats, WistarSchwann CellsSciatic Nerve

Identifiers

PMID25975801
PMCPMC4889908
OpenAlexW250925114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.