ArticleBMC genomics2015
Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Genetic mechanisms underlying spermatic and testicular traits within and among cattle breeds: systematic review and prioritization of GWAS results.Journal of animal science · 2018Pooled it
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- Genotype-By-Environment Interaction for Scrotal Circumference in Young Nellore Bulls Under Pasture and Feedlot Conditions and Its Correlation With Days to Calving.Animal genetics · 2026Article
- Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomes.Journal of assisted reproduction and genetics · 2025Article
- Genetic parameters and genome-wide association studies including the X chromosome for various reproduction and semen quality traits in Nellore cattle.BMC genomics · 2025Article
- Genetic and phenotypic parameters for sexual precocity and parasite resistance traits in Nellore cattle.Journal of applied genetics · 2023Article
- Genetic parameters for various semen production and quality traits and indicators of male and female reproductive performance in Nellore cattle.BMC genomics · 2023Article
- Genome-Wide Identification of KiwifruitInternational journal of molecular sciences · 2023Article
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- The genetic history of Mayotte and Madagascar cattle breeds mirrors the complex pattern of human exchanges in Western Indian Ocean.G3 (Bethesda, Md.) · 2022Article
- Effect of genomic X-chromosome regions on Nelore bull fertility.Journal of applied genetics · 2021Article
- Whole-Genome Sequencing and Characterization of Buffalo Genetic Resources: Recent Advances and Future Challenges.Animals : an open access journal from MDPI · 2021Review
- The effect of mitochondrial DNA polymorphisms on cattle reproduction.Molecular biology reports · 2021Article
- Genome-wide association study to identify genomic regions and positional candidate genes associated with male fertility in beef cattle.Scientific reports · 2020Article
- X chromosome variants are associated with male fertility traits in two bovine populations.Genetics, selection, evolution : GSE · 2020Article
- The role of BAMBI in regulating adipogenesis and myogenesis and the association between its polymorphisms and growth traits in cattle.Molecular biology reports · 2020Article
- Gene transfer and nucleotide sequence evolution by Gossypium cytoplasmic genomes indicates novel evolutionary characteristics.Plant cell reports · 2020Article
- Article
- Review: Genomics of bull fertility.Animal : an international journal of animal bioscience · 2018Review
- Review: Sperm-oocyte interactions and their implications for bull fertility, with emphasis on the ubiquitin-proteasome system.Animal : an international journal of animal bioscience · 2018Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious genome-wide association analyses identified QTL regions in the X chromosome for percentage of normal sperm and scrotal circumference in Brahman and Tropical Composite cattle. These traits are important to be studied because they are indicators of male fertility and are correlated with female sexual precocity and reproductive longevity. The aim was to investigate candidate genes in these regions and to identify putative causative mutations that influence these traits. In addition, we tested the identified mutations for female fertility and growth traits.
resultsUsing a combination of bioinformatics and molecular assay technology, twelve non-synonymous SNPs in eleven genes were genotyped in a cattle population. Three and nine SNPs explained more than 1% of the additive genetic variance for percentage of normal sperm and scrotal circumference, respectively. The SNPs that had a major influence in percentage of normal sperm were mapped to LOC100138021 and TAF7L genes; and in TEX11 and AR genes for scrotal circumference. One SNP in TEX11 was explained ~13% of the additive genetic variance for scrotal circumference at 12 months. The tested SNP were also associated with weight measurements, but not with female fertility traits.
conclusionsThe strong association of SNPs located in X chromosome genes with male fertility traits validates the QTL. The implicated genes became good candidates to be used for genetic evaluation, without detrimentally influencing female fertility traits.
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