Evidence map›Paper›PMID 25975676›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2015

The biology of cancer-related fatigue: a review of the literature.

Leorey N Saligan, Karin Olson, Kristin Filler, David Larkin, Fiona Cramp, Sriram Yennurajalingam, Yennu Sriram, Carmen P Escalante, Auro del Giglio, Kord M Kober and 4 more

Erratum issued Registry-linked trialOpen access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03952624 (Patient-Centered Assessment of Symptoms and Outcomes), which is not on this map. Cited by 175 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 14 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03952624 active not recruitingnot on this mapstarted 2019, after this paper: background citation

Patient-Centered Assessment of Symptoms and Outcomes

TypeobservationalSponsorNational Center for Complementary and Integrative Health (NCCIH)Ran2019 to 2027Enrolled37ConditionsFatigue, Cancer, CFS, ME/CFS
3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 14 syntheses or guidelines pooled it, 303 citations in OpenAlex.

  1. Pooled it
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  5. Efficacy and safety of moxibustion on cancer-related fatigue: a systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  7. Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Pooled it
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  10. Exercise on quality of life and cancer-related fatigue for lymphoma survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  16. Dexamethasone for 12 weeks for reducing fatigue in patients receiving palliative chemotherapy: A Phase 3, Placebo-Controlled, Randomized Controlled Trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 5 countries.

Leorey N SaliganNational Institute of Nursing Research, National Institutes of Health, 9000 Rockville Pike, Building 3, Room 5E14, Bethesda, MD, 20892, USA, saliganl@mail.nih.gov.
Karin Olson
Kristin Filler
David Larkin
Fiona Cramp
Sriram Yennurajalingam
Yennu Sriram
Carmen P Escalante
Auro del Giglio
Kord M Kober
Jayesh Kamath
Oxana Palesh
Karen Mustian
Multinational Association of Supportive Care in Cancer Fatigue Study Group-Biomarker Working Group
The University of Texas MD Anderson Cancer Center · USHospital São Paulo · BRNational Institute of Nursing Research · USNational Institutes of Health · USStanford Medicine · USUConn Health · USUniversity of Alberta · CAUniversity of California, San Francisco · USUniversity of Canberra · AUUniversity of Rochester Medical Center · USUniversity of the West of England · GB

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Investigating Correlates of Fatigue in Cancer Patients receiving TreatmentZIANR000020 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI SALIGAN, LEOREY · 2011 to 2022
$15.1M
Investigating Molecular-Genetic Correlates of FatigueZIANR000019 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI SALIGAN, LEOREY · 2010 to 2025
$12.8M
Brief Behavioral Intervention for Insomnia During ChemotherapyR01CA181659 · NCI · STANFORD UNIVERSITY · PI PALESH, OXANA G · 2014 to 2018
$3.1M
Yoga Versus CBT-I for Insomnia in Cancer Survivors and Biobehavioral MechanismsR01CA181064 · NCI · UNIVERSITY OF ROCHESTER · PI MUSTIAN, KAREN M. · 2014 to 2019
$3.1M
Aerobic and Resistance Exercise for Cancer-Related Fatigue During RadiationK07CA120025 · NCI · UNIVERSITY OF ROCHESTER · PI MUSTIAN, KAREN M. · 2007 to 2011
$678k
Intramural NIH HHS ZIA NR000019NCI NIH HHS K07 CA120025NCI NIH HHS K07CA120025NCI NIH HHS R01 CA181064NCI NIH HHS R01 CA181659NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

purposeUnderstanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate.

methodsThis review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group-Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords "cancer" and "fatigue" resulting in 3811 articles. Articles published before 2010 and those with samples <50 were excluded, leaving 75 articles for full-text review. Of the 75 articles, 28 were further excluded for not investigating the associations of biomarkers and CRF.

resultsOf the 47 articles reviewed, 25 were cross-sectional and 22 were longitudinal studies. More than half (about 70 %) were published recently (2010-2013). Almost half (45 %) enrolled breast cancer participants. The majority of studies assessed fatigue using self-report questionnaires, and only two studies used clinical parameters to measure fatigue.

conclusionsThe findings from this review suggest that CRF is linked to immune/inflammatory, metabolic, neuroendocrine, and genetic biomarkers. We also identified gaps in knowledge and made recommendations for future research.

Indexed as

Cross-Sectional StudiesFatigueFemaleHumansLongitudinal StudiesMaleNeoplasmsSurveys and Questionnaires

Identifiers

PMID25975676
PMCPMC4484308
OpenAlexW2135412225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.