Evidence map›Paper›PMID 25975657›Full record

ReviewEuropean heart journal2015

The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction.

John S Floras, Piotr Ponikowski

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European heart journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 5 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 5 syntheses or guidelines pooled it, 246 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Acute right-sided transcutaneous vagus nerve stimulation improves cardio-vagal baroreflex gain in patients with chronic heart failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Impact of eplerenone on major cardiovascular outcomes in patients with systolic heart failure according to baseline heart rate.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Trial
  12. Trial
  13. Trial
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Autonomic effects of simulated periodic breathing in patients with chronic heart failure on contemporary guideline-directed therapy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

John S FlorasUniversity Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Suite 1614, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5 john.floras@utoronto.ca.
Piotr PonikowskiDepartment for Heart Disease, Medical University, Clinical Military Hospital, Wroclaw, Poland.
University Health Network · CAWroclaw Medical University · PL

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

Cardiovascular autonomic imbalance, a cardinal phenotype of human heart failure, has adverse implications for symptoms during wakefulness and sleep; for cardiac, renal, and immune function; for exercise capacity; and for lifespan and mode of death. The objectives of this Clinical Review are to summarize current knowledge concerning mechanisms for disturbed parasympathetic and sympathetic circulatory control in heart failure with reduced ejection fraction and its clinical and prognostic implications; to demonstrate the patient-specific nature of abnormalities underlying this common phenotype; and to illustrate how such variation provides opportunities to improve or restore normal sympathetic/parasympathetic balance through personalized drug or device therapy.

Indexed as

Afferent PathwaysAutonomic Nervous System DiseasesBaroreflexBiomarkersCentral Nervous System DiseasesChemoreceptor CellsHeart FailureHeart RateHumansKidneyMechanoreceptorsMuscle, SkeletalPrognosisSleep Wake DisordersStroke VolumeBiomarkersBaroreceptor reflexChemoreceptor reflexExerciseHeart failureHumanParasympathetic nervous systemSleep apnoeaSympathetic nervous system

Identifiers

PMID25975657
PMCPMC4528097
OpenAlexW1955267296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.