Observational studyBMC emergency medicine2015
Prospective study of recovery from copperhead snake envenomation: an observational study.
Observational study in BMC emergency medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01651299 (Observational Study of Recovery From Copperhead Snake Envenomation), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observational Study of Recovery From Copperhead Snake Envenomation
Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation.The western journal of emergency medicine · 2019Trial
- Capacity of community health centers to treat snakebite envenoming in indigenous territories of the Brazilian Amazon.Toxicon : official journal of the International Society on Toxinology · 2024Article
- Total CroFab and Anavip Antivenom Vial Administration in US Rattlesnake Envenomations: 2019-2021.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023Article
- Article
- Contextualizing the Impact of Snakebite Envenoming on Patients: A Qualitative Content Analysis of Patient-Specific Functional Scale Activities Using the International Classification of Functioning, Disability and Health.International journal of environmental research and public health · 2021Article
- Neotropical Rattlesnake (Toxins · 2020Article
- Validity and reliability of telephone administration of the patient-specific functional scale for the assessment of recovery from snakebite envenomation.PLoS neglected tropical diseases · 2019Article
- The validity, reliability and minimal clinically important difference of the patient specific functional scale in snake envenomation.PloS one · 2019Article
- Current Management of Copperhead Snakebites in Missouri.Missouri medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough much is known about signs, symptoms, and management in the acute phase of crotaline snake envenomation, little is known about signs, symptoms, function, and quality of life during the recovery phase. The purpose of this observational pilot investigation is to evaluate the utility of several clinical outcome instruments in the setting of copperhead snakebite, and to characterize the clinical course of recovery.
methodsThis is a multi-center prospective, open-label, observational study of patients envenomated by copperhead snakes. We administered the Disabilities of the Arm, Shoulder, and Hand (DASH), Lower Extremity Functional Scale (LEFS), Patient-Specific Functional Scale (PSFS), Work Productivity and Ability Impairment: Special Health Problem (WPAI: SHP), Patients' Global Impression of Change (PGIC), Patient's Global Assessment of Recovery (PGAR), and SF-36 instruments, obtained numeric pain rating scales, and measured grip strength, walking speed, and swelling prior to hospital discharge and 3, 7, 14, 21, and 28 days after envenomation.
results20 subjects were enrolled; none were lost to follow-up. Most (80%) had moderate severity swelling, and most (75%) received antivenom. Across the broad range of measures, abnormalities of pain, swelling, impairments of physical and role function, and quality of life persisted for 7-14 days in most subjects. Validated self-reported outcome measures, such as the DASH, LEFS, PSFS, PGIC, SF-36, and the daily activities impairment portion of the WPAI: SHP were more responsive than measurements of swelling or walking speed. Data quality issues limited the utility of the work impairment portion of the WPAI: SHP. Residual signs, symptoms, and impairment in some subjects lasted through the 28-day study period. The study design precluded any assessment of the effectiveness of antivenom.
conclusionsSigns, symptoms, impaired function, and decreased quality of life typically last 7 - 14 days after copperhead envenomation. Several tools appear responsive and useful in studying recovery from pit viper envenomation.
trial registrationClinicalTrials.gov NCT01651299.
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