Evidence map›Paper›PMID 25975296›Full record

ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2015

[Therapeutical effects of pleural injecting recombinant human endostain to 
malignant pleural effusion nude mice model].

Ming Zhou, Min Li, Huaping Yang, Chengping Hu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ming ZhouDepartment of Respiratory Medicine, Xiangya Hospital, Center South University, Hunan 410008, China.
Min LiDepartment of Respiratory Medicine, Xiangya Hospital, Center South University, Hunan 410008, China.
Huaping YangDepartment of Respiratory Medicine, Xiangya Hospital, Center South University, Hunan 410008, China.
Chengping HuDepartment of Respiratory Medicine, Xiangya Hospital, Center South University, Hunan 410008, China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe prognosis of malignant pleural effusion (MPE) was poor, injecting anti-angiogenesis agents in pleural cavity might be to reducing the volume of pleural effusion. The aim of this study is to investigate the therapeutical effect of pleural injection of recombinant human endostain, cisplatin and recombinant human endostain combined with cisplatin to MPE nude mice.

methodsMPE model was built by intrpleural injection of Lewis lung cancer cells (LCC) into BALB/c nude mice. Intrpleural injection of recombinant human endostain (E), cisplatin (P) and recombinant human endostain combined with cisplatin (EP) was performed, MPE volume was measured, immunohistochemistry of CD31 was carried out to calculate micro vessel density (MVD), angiogenesis and apoptosis gene expression was detected.

resultsMPE volume was reduced by intrapleiral injection of recombinant human endostain and recombinant human endostain combined with cisplatin, MPE volume was positive correlated with MVD. Vescular epidermal growth factor-α (VEGF-α) expression reduced simultaneously with expression of hypoxia induced factor-1 (HIF1-α) elevated at the same time.

conclusionsMPE model could be made by intrapleural injection of LLC. Intrapleural injection of recombinant human endostain could reduce MPE volume of nude mice. The potential molecular mechanism of the therapeutical effects of intapleural injection of recombiant endostatin might be related to the downregulation of VEGF-α expression and neovascularization.
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Indexed as

AnimalsCell Line, TumorDisease Models, AnimalEndostatinsFemaleHumansHypoxia-Inducible Factor 1MiceMice, Inbred BALB CMice, NudePleural CavityPleural Effusion, MalignantPleural NeoplasmsRecombinant ProteinsVascular Endothelial Growth Factor AEndostatinsHypoxia-Inducible Factor 1Recombinant ProteinsVascular Endothelial Growth Factor A

Identifiers

PMID25975296
PMCPMC6015210
OpenAlexW1505037295

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.