ArticleIEEE transactions on biomedical circuits and systems2016
A CMOS Neural Interface for a Multichannel Vestibular Prosthesis.
Article in IEEE transactions on biomedical circuits and systems, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- An Event based Body Coupled Transdural Telemetry for Intracortical Brain Computer Interfaces.Communications engineering · 2026Article
- Effects of Electrode Position on Vestibular Implant Performance in Rhesus Macaque.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Bioelectronic Medicines-A Novel Approach of Therapeutics in Current Epoch.Current pharmaceutical design · 2025Review
- Recent Advancements in Bioelectronic Medicine: A Review.Current drug delivery · 2024Review
- [Recent progress in vestibular prosthesis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Review
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- A Hybrid Bipolar Active Charge Balancing Technique with Adaptive Electrode Tissue Interface (ETI) Impedance Variations for Facial Paralysis Patients.Sensors (Basel, Switzerland) · 2022Article
- Binocular 3D otolith-ocular reflexes: responses of chinchillas to prosthetic electrical stimulation targeting the utricle and saccule.Journal of neurophysiology · 2020Article
- Vestibular, locomotor, and vestibulo-autonomic research: 50 years of collaboration with Bernard Cohen.Journal of neurophysiology · 2020Review
- Implantable Direct Current Neural Modulation: Theory, Feasibility, and Efficacy.Frontiers in neuroscience · 2019Review
- Organic Bioelectronics: Materials and Biocompatibility.International journal of molecular sciences · 2018Review
- Severe streptomycin ototoxicity in the mouse utricle leads to a flat epithelium but the peripheral neural degeneration is delayed.Hearing research · 2017Article
- A CMOS Current Steering Neurostimulation Array With Integrated DAC Calibration and Charge Balancing.IEEE transactions on biomedical circuits and systems · 2017Article
- A Low-Power ASIC Signal Processor for a Vestibular Prosthesis.IEEE transactions on biomedical circuits and systems · 2016Article
- Vestibular compensation: extended review.Frontiers in neurologyReview
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
We present a high-voltage CMOS neural-interface chip for a multichannel vestibular prosthesis (MVP) that measures head motion and modulates vestibular nerve activity to restore vision- and posture-stabilizing reflexes. This application specific integrated circuit neural interface (ASIC-NI) chip was designed to work with a commercially available microcontroller, which controls the ASIC-NI via a fast parallel interface to deliver biphasic stimulation pulses with 9-bit programmable current amplitude via 16 stimulation channels. The chip was fabricated in the ONSemi C5 0.5 micron, high-voltage CMOS process and can accommodate compliance voltages up to 12 V, stimulating vestibular nerve branches using biphasic current pulses up to 1.45±0.06 mA with durations as short as 10 μs/phase. The ASIC-NI includes a dedicated digital-to-analog converter for each channel, enabling it to perform complex multipolar stimulation. The ASIC-NI replaces discrete components that cover nearly half of the 2nd generation MVP (MVP2) printed circuit board, reducing the MVP system size by 48% and power consumption by 17%. Physiological tests of the ASIC-based MVP system (MVP2A) in a rhesus monkey produced reflexive eye movement responses to prosthetic stimulation similar to those observed when using the MVP2. Sinusoidal modulation of stimulus pulse rate from 68-130 pulses per second at frequencies from 0.1 to 5 Hz elicited appropriately-directed slow phase eye velocities ranging in amplitude from 1.9-16.7 °/s for the MVP2 and 2.0-14.2 °/s for the MVP2A. The eye velocities evoked by MVP2 and MVP2A showed no significant difference ( t-test, p=0.34), suggesting that the MVP2A achieves performance at least as good as the larger MVP2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.