Evidence map›Paper›PMID 25974300›Full record

ReviewCell host & microbe2015

An integrative view of microbiome-host interactions in inflammatory bowel diseases.

Marta Wlodarska, Aleksandar D Kostic, Ramnik J Xavier

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05720793 (A Clinical Trial to Evaluate the Safety and Tolerability of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder), which is not on this map. Cited by 163 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 2 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05720793 phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

A Clinical Trial to Evaluate the Safety and Tolerability of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder

TypeinterventionalSponsorValerie TaylorRan2023 to 2024Enrolled20ConditionsObsessive-Compulsive DisorderArmsFMT Capsule + SIMBA Capsule
3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 2 syntheses or guidelines pooled it, 287 citations in OpenAlex.

  1. Polymorphism rs6478109 in theThe Journal of international medical research · 2020
    Pooled it
  2. Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Pooled it
  3. Trial
  4. Trial
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  6. The role of adhesins ofGut microbes · 2026
    Review
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  18. Lipidomics, Microbiota, and IntestinalInternational journal of molecular sciences · 2025
    Review
  19. Article
  20. Article

103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marta WlodarskaThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Aleksandar D KosticThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Ramnik J XavierThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: xavier@molbio.mgh.harvard.edu.
Broad Institute · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Characterizing the gut microbial ecosystem for diagnosis and therapy in IBDU54DK102557 · NIDDK · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS, XAVIER, RAMNIK J · 2014 to 2015
$7.7M
Autophagy genes and the microbiome in Crohn's DiseaseR01DK092405 · NIDDK · BROAD INSTITUTE, INC. · PI XAVIER, RAMNIK J · 2012 to 2014
$2.0M
NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK092405NIDDK NIH HHS U54 DK102557
6 · The paper itself

Abstract

The intestinal microbiota, which is composed of bacteria, viruses, and micro-eukaryotes, acts as an accessory organ system with distinct functions along the intestinal tract that are critical for health. This review focuses on how the microbiota drives intestinal disease through alterations in microbial community architecture, disruption of the mucosal barrier, modulation of innate and adaptive immunity, and dysfunction of the enteric nervous system. Inflammatory bowel disease is used as a model system to understand these microbial-driven pathologies, but the knowledge gained in this space is extended to less-well-studied intestinal diseases that may also have an important microbial component, including environmental enteropathy and chronic colitis-associated colorectal cancer.

Indexed as

Host-Pathogen InteractionsDysbiosisGastrointestinal MicrobiomeGastrointestinal TractHumansInflammatory Bowel Diseases

Identifiers

PMID25974300
PMCPMC4498258
OpenAlexW2148770916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.