ArticleInternational wound journal2016
Amniotic membrane is a potential regenerative option for chronic non-healing wounds: a report of five cases receiving dehydrated human amnion/chorion membrane allograft.
Article in International wound journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of Vacuum Compression Therapy on Healing of Chronic Lower Limb Ulcers: A Randomised Controlled Study.International wound journal · 2026Trial
- Treatment of chronic diabetic lower extremity ulcers with advanced therapies: a prospective, randomised, controlled, multi-centre comparative study examining clinical efficacy and cost.International wound journal · 2016Trial
- Amniotic membrane scaffold in conjunction with Biodentine for apexification: a clinical study on immature permanent teeth.BMC research notes · 2026Article
- Comparing Amniotic Membranes to Other Bioengineered Skin Substitutes in Wound Healing: A Propensity Score-Matched Analysis.Journal of clinical medicine · 2025Article
- Effectiveness of epidural amniotic fluid injection for low back pain.Interventional pain medicine · 2025Article
- Placental-Derived Biomaterials and Their Application to Wound Healing: A Review.Bioengineering (Basel, Switzerland) · 2023Review
- Mesenchymal stem cells' seeded amniotic membrane as a tissue-engineered dressing for wound healing.Drug delivery and translational research · 2022Article
- Dehydrated human amnion/chorion membrane allografts for myelomeningocele and wound reconstruction.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Review
- Case Report: Freeze-Dried Human Amniotic Membrane Allograft for the Treatment of Chronic Wounds: Results of a Multicentre Observational Study.Frontiers in bioengineering and biotechnology · 2021Article
- Benefits of cryopreserved human amniotic membranes in association with conventional treatments in the management of full-thickness burns.International wound journal · 2019Article
- Evaluation of dehydrated human umbilical cord biological properties for wound care and soft tissue healing.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Amniotic membrane as novel scaffold for human iPSC-derived cardiomyogenesis.In vitro cellular & developmental biology. Animal · 2019Article
- Novel Role of Dehydrated Human Amnion/Chorion Membrane in Healing of Denuded Ureter in Robot-Assisted Excision of Endometriosis.Case reports in obstetrics and gynecology · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
A case series of five patients with a total of six chronic non-healing wounds (>30 day duration) were non-randomly selected to evaluate the performance, safety and handling properties of dehydrated human amnion/chorion membrane allograft, an amniotic membrane scaffolding product. The patients had lower extremity wounds that had previously failed standard of care within a university outpatient/inpatient wound healing programme. Five wounds treated with dehydrated amnion/chorion membrane allograft showed a mean 43% area reduction from baseline (51% median) at 3 weeks into treatment and completely healed with a 64-day median time to closure (SD ±27·6 days). One wound worsened at 3 weeks and was found to have a complete central vein obstruction that was treated with long-term mild compression but still eventually healed at 6 months. Removing this outlier, the four responding wounds had a 72% mean and 69% median change in area from baseline, at the 3 week point. All five patients received only one application of dehydrated human amnion/chorion membrane allograft, and there were no adverse events. The product was easy to use, administer and handle. In summary, dehydrated human amnion/chorion membrane allograft appears to be a safe, effective and easy to use therapy for chronic non-healing wounds. This study describes the details of these clinical cases and provides an overview of the current evidence on the use of amniotic tissue in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.