ArticleNature protocols2015
Preparation of compact biocompatible quantum dots using multicoordinating molecular-scale ligands based on a zwitterionic hydrophilic motif and lipoic acid anchors.
Article in Nature protocols, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- Elemental Composition and Degradation Rate Impact the Biocompatibility of Copper Chalcogenide Nanocrystals.ACS applied materials & interfaces · 2026Article
- Elemental Composition and Degradation Rate Impact the Biocompatibility of Copper Chalcogenide Nanocrystals.bioRxiv : the preprint server for biology · 2026Article
- Review
- Inter-Nanoparticle FRET for Biosensing: Photophysics Versus Size.Angewandte Chemie (International ed. in English) · 2025Review
- Ring-Opening Polymerization of Surface Ligands Enables Versatile Optical Patterning and Form Factor Flexibility in Quantum Dot Assemblies.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Quantum Dots: Synthesis, Antibody Conjugation, and HER2-Receptor Targeting for Breast Cancer Therapy.Journal of functional biomaterials · 2021Review
- Organic-to-Aqueous Phase Transfer of Alloyed AgInSNanomaterials (Basel, Switzerland) · 2021Article
- Colloidally Stable CdS Quantum Dots in Water with Electrostatically Stabilized Weak-Binding, Sulfur-Free Ligands.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- pH-Dependent structure of water-exposed surfaces of CdSe quantum dots.Chemical communications (Cambridge, England) · 2019Article
- Small protein sequences can induce cellular uptake of complex nanohybrids.Beilstein journal of nanotechnology · 2019Article
- Efficient Assembly of Quantum Dots with Homogenous Glycans Derived from Natural N-Linked Glycoproteins.Bioconjugate chemistry · 2018Article
- Article
- Ultraefficient Cap-Exchange Protocol To Compact Biofunctional Quantum Dots for Sensitive Ratiometric Biosensing and Cell Imaging.ACS applied materials & interfaces · 2017Article
- Organic-to-Aqueous Phase Transfer of Cadmium Chalcogenide Quantum Dots using a Sulfur-Free Ligand for Enhanced Photoluminescence and Oxidative Stability.Chemistry of materials : a publication of the American Chemical Society · 2016Article
- 3D tracking of single nanoparticles and quantum dots in living cells by out-of-focus imaging with diffraction pattern recognition.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Luminescent quantum dots (QDs) can potentially be used for many biological experiments, provided that they are constructed in such a way as to be stable in biological matrices. Furthermore, QDs that are compact in size and easy to couple to biomolecules can be readily used for applications ranging from protein tracking to vasculature imaging. In this protocol, we describe the preparation of ligands comprising either one or two lipoic acid (LA) groups chemically linked to a zwitterion moiety. These ligands are then used to functionalize luminescent QDs via a photochemical transformation of LA. This route produces nanocrystals that are compact in size and stable over a broad range of conditions. In addition, the resulting QDs are readily self-assembled with polyhistidine-appended proteins. This mode of conjugation maintains the protein biological activity and its orientation, yielding highly promising fluorescent conjugates that can be used for imaging and sensing. The protocol in its entirety can be completed in 3 weeks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.