ArticleScientific reports2015
A new gender-specific model for skin autofluorescence risk stratification.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Skin autofluorescence is associated with blood glucose levels, especially in children with type 1 diabetes.Frontiers in clinical diabetes and healthcare · 2025Pooled it
- The relationship between ultra-processed food consumption and advanced glycation end products in university students: evidence from the skin autofluorescence method.BMC nutrition · 2025Article
- Usefulness of Skin Autofluorescence as a Biomarker of Acute Oxidative Stress in Young Male Japanese Long-Distance Runners: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2022Article
- Skin optical properties in the obese and their relation to body mass index: a review.Journal of biomedical optics · 2022Review
- Clinical Significance of Non-invasive Skin Autofluorescence Measurement in Patients with Diabetes: A Systematic Review and Meta-analysis.EClinicalMedicine · 2021Article
- Skin intrinsic fluorescence scores are a predictor of all-cause mortality risk in type 1 diabetes: The Epidemiology of Diabetes Complications study.Journal of diabetes and its complications · 2021Observational
- Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation.Antioxidants (Basel, Switzerland) · 2020Article
- Characterization of human cutaneous tissue autofluorescence: implications in topical drug delivery studies with fluorescence microscopy.Biomedical optics express · 2018Article
- A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness.Pulse (Basel, Switzerland) · 2017Article
- Ethnicity and skin autofluorescence-based risk-engines for cardiovascular disease and diabetes mellitus.PloS one · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advanced glycation endproducts (AGEs) are believed to play a significant role in the pathophysiology of a variety of diseases including diabetes and cardiovascular diseases. Non-invasive skin autofluorescence (SAF) measurement serves as a proxy for tissue accumulation of AGEs. We assessed reference SAF and skin reflectance (SR) values in a Saudi population (n = 1,999) and evaluated the existing risk stratification scale. The mean SAF of the study cohort was 2.06 (SD = 0.57) arbitrary units (AU), which is considerably higher than the values reported for other populations. We show a previously unreported and significant difference in SAF values between men and women, with median (range) values of 1.77 AU (0.79-4.84 AU) and 2.20 AU (0.75-4.59 AU) respectively (p-value « 0.01). Age, presence of diabetes and BMI were the most influential variables in determining SAF values in men, whilst in female participants, SR was also highly correlated with SAF. Diabetes, hypertension and obesity all showed strong association with SAF, particularly when gender differences were taken into account. We propose an adjusted, gender-specific disease risk stratification scheme for Middle Eastern populations. SAF is a potentially valuable clinical screening tool for cardiovascular risk assessment but risk scores should take gender and ethnicity into consideration for accurate diagnosis.
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