ReviewNatural product reports2015
Conformation-activity relationships of polyketide natural products.
Review in Natural product reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Article
- Boron's Double Edge-Antibiotics, Toxins, and the Fine Line Between Them.Molecules (Basel, Switzerland) · 2026Review
- Nucleophilic addition promoted ring rearrangement-aromatization in aza-/thio-sesquiterpenoid biosynthesis.Nature communications · 2025Article
- Conformational dynamics and molecular interactions of natural products: unveiling functional structures in biological membranes.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Computationally Assisted Analysis of NMR Chemical Shifts as a Tool in Conformational Analysis.Organic letters · 2024Article
- Article
- The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases.Communications biology · 2022Article
- Article
- Structures of three disubstituted [13]-macro-di-lac-tones reveal effects of substitution on macrocycle conformation.Acta crystallographica. Section E, Crystallographic communications · 2020Article
- Synthetic biology enabling access to designer polyketides.Current opinion in chemical biology · 2020Review
- Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases.Synthetic and systems biotechnology · 2020Review
- Stereospecific Cross-Coupling Reactions Provide Conformationally-Biased Arylalkanes with Anti-Leukemia Activity.Israel journal of chemistry · 2020Article
- Article
- Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration.Organic & biomolecular chemistry · 2018Article
- ReAngewandte Chemie (International ed. in English) · 2017Article
- Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues.International journal of molecular sciences · 2017Article
- Article
- Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly.Chemical communications (Cambridge, England) · 2016Review
- Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.Journal of the American Chemical Society · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Polyketides represent an important class of secondary metabolites that interact with biological targets connected to a variety of disease-associated pathways. Remarkably, nature's assembly lines, polyketide synthases, manufacture these privileged structures through a combinatorial mixture of just a few structural units. This review highlights the role of these structural elements in shaping a polyketide's conformational preferences, the use of computer-based molecular modeling and solution NMR studies in the identification of low-energy conformers, and the importance of conformational analogues in probing the bound conformation. In particular, this review covers several examples wherein conformational analysis complements classic structure-activity relationships in the design of biologically active natural product analogues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.