Evidence map›Paper›PMID 25973916›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2015

Efficient Radioisotope Energy Transfer by Gold Nanoclusters for Molecular Imaging.

Olga Volotskova, Conroy Sun, Jason H Stafford, Ai Leen Koh, Xiaowei Ma, Zhen Cheng, Bianxiao Cui, Guillem Pratx, Lei Xing

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Radionuclide-Activated Nanomaterials and Their Biomedical Applications.Angewandte Chemie (International ed. in English) · 2019
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Olga VolotskovaDepartment of Radiation Oncology, Stanford University, Stanford, CA, 94305, USA.
Conroy SunDepartment of Radiation Oncology, Stanford University, Stanford, CA, 94305, USA.
Jason H StaffordDepartment of Radiation Oncology, Stanford University, Stanford, CA, 94305, USA.
Ai Leen KohStanford Nanocharacterization Laboratory, Stanford University, Stanford, CA, 94305, USA.
Xiaowei MaDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Zhen ChengDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Bianxiao CuiDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Guillem PratxDepartment of Radiation Oncology, Stanford University, Stanford, CA, 94305, USA.
Lei XingDepartment of Radiation Oncology, Stanford University, Stanford, CA, 94305, USA.
Stanford University · US

Funding

Computational Tools for Next Generation Volumetric Cone Beam Computed TomographyR01EB016777 · NIBIB · STANFORD UNIVERSITY · PI XING, LEI · 2013 to 2016
$2.1M
NIBIB NIH HHS 1R01 EB016777NIBIB NIH HHS R01 EB016777
6 · The paper itself

Abstract

Beta-emitting isotopes Fluorine-18 and Yttrium-90 are tested for their potential to stimulate gold nanoclusters conjugated with blood serum proteins (AuNCs). AuNCs excited by either medical radioisotope are found to be highly effective ionizing radiation energy transfer mediators, suitable for in vivo optical imaging. AuNCs synthesized with protein templates convert beta-decaying radioisotope energy into tissue-penetrating optical signals between 620 and 800 nm. Optical signals are not detected from AuNCs incubated with Technetium-99m, a pure gamma emitter that is used as a control. Optical emission from AuNCs is not proportional to Cerenkov radiation, indicating that the energy transfer between the radionuclide and AuNC is only partially mediated by Cerenkov photons. A direct Coulombic interaction is proposed as a novel and significant mechanism of energy transfer between decaying radionuclides and AuNCs.

Indexed as

Energy TransferAnimalsCattleCell Line, TumorGoldHumansMetal NanoparticlesMiceMolecular ImagingRadioisotopesReproducibility of ResultsSerum Albumin, BovineGoldRadioisotopesSerum Albumin, Bovinecerenkov radiationgold nanoclustersimaging, radioisotope energy transferoptical imagingradioisotopes

Identifiers

PMID25973916
PMCPMC12121654
OpenAlexW2106799416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.