Evidence map›Paper›PMID 25973911›Full record

ArticlePLoS genetics2015

Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.

Ashley P Ng, Yifang Hu, Donald Metcalf, Craig D Hyland, Helen Ierino, Belinda Phipson, Di Wu, Tracey M Baldwin, Maria Kauppi, Hiu Kiu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Ashley P NgThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
Yifang HuThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Donald MetcalfThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
Craig D HylandThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Helen IerinoThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Belinda PhipsonThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria, Australia.
Di WuCentre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia; Department of Statistics, Harvard University, Cambridge, Massachusetts, United States of America.
Tracey M BaldwinThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Maria KauppiThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
Hiu KiuThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
Ladina Di RagoThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Douglas J HiltonThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
Gordon K SmythThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria, Australia.
Warren S AlexanderThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
Walter and Eliza Hall Institute of Medical Research · AUUniversity of Melbourne · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Down syndrome (DS), with trisomy of chromosome 21 (HSA21), is the commonest human aneuploidy. Pre-leukemic myeloproliferative changes in DS foetal livers precede the acquisition of GATA1 mutations, transient myeloproliferative disorder (DS-TMD) and acute megakaryocytic leukemia (DS-AMKL). Trisomy of the Erg gene is required for myeloproliferation in the Ts(1716)65Dn DS mouse model. We demonstrate here that genetic changes specifically attributable to trisomy of Erg lead to lineage priming of primitive and early multipotential progenitor cells in Ts(1716)65Dn mice, excess megakaryocyte-erythroid progenitors, and malignant myeloproliferation. Gene expression changes dependent on trisomy of Erg in Ts(1716)65Dn multilineage progenitor cells were correlated with those associated with trisomy of HSA21 in human DS hematopoietic stem and primitive progenitor cells. These data suggest a role for ERG as a regulator of hematopoietic lineage potential, and that trisomy of ERG in the context of DS foetal liver hemopoiesis drives the pre-leukemic changes that predispose to subsequent DS-TMD and DS-AMKL.

Indexed as

TrisomyADP-ribosyl Cyclase 1AllelesAnimalsAntigens, CD34Cell LineageCell ProliferationChromosomes, Human, Pair 21Disease Models, AnimalDown SyndromeErythroid CellsGene Expression ProfilingGene Expression RegulationGenotypeHematopoiesisHematopoietic SystemADP-ribosyl Cyclase 1Antigens, CD34ERG protein, humanERG protein, mouseOncogene ProteinsProto-Oncogene Proteins c-etsTrans-ActivatorsTranscriptional Regulator ERGTranscription Factors

Identifiers

PMID25973911
PMCPMC4431731
OpenAlexW1963456997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.