ArticlePLoS genetics2015
Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Large-scale human genomic resources drive innovations toward forensic intelligent source attribution and precision identification.International journal of legal medicine · 2026Review
- Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm.Science China. Life sciences · 2025Review
- Uniparental Inheritance and Recombination as Strategies to Avoid Competition and Combat Muller's Ratchet among Mitochondria in Natural Populations of the FungusJournal of fungi (Basel, Switzerland) · 2023Article
- The interplay of dopamine metabolism abnormalities and mitochondrial defects in the pathogenesis of schizophrenia.Translational psychiatry · 2022Review
- The role of mitochondria in rheumatic diseases.Nature reviews. Rheumatology · 2022Review
- Article
- Interference of nuclear mitochondrial DNA segments in mitochondrial DNA testing resembles biparental transmission of mitochondrial DNA in humans.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- Mitochondrial function in development and disease.Disease models & mechanisms · 2021Review
- Evidence for multi-copy Mega-NUMTs in the human genome.Nucleic acids research · 2021Article
- Natural and Artificial Mechanisms of Mitochondrial Genome Elimination.Life (Basel, Switzerland) · 2021Review
- Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Metabolic effects of bezafibrate in mitochondrial disease.EMBO molecular medicine · 2020Observational
- Mitochondrial DNA heteroplasmy in disease and targeted nuclease-based therapeutic approaches.EMBO reports · 2020Review
- Selfish Mitonuclear Conflict.Current biology : CB · 2019Review
- Paternal comeback in mitochondrial DNA inheritance.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies.Oncology reviews · 2019Article
- A Nuclear mtDNA Concatemer (Mega-NUMT) Could Mimic Paternal Inheritance of Mitochondrial Genome.Frontiers in genetics · 2019Article
- Biparental Inheritance of Mitochondrial DNA in Humans.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mitochondrial genetic medicine.Nature genetics · 2018Review
- Mitophagy, a potential therapeutic target for stroke.Journal of biomedical science · 2018Review
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8 authors.
Funding
Abstract
Recent reports have questioned the accepted dogma that mammalian mitochondrial DNA (mtDNA) is strictly maternally inherited. In humans, the argument hinges on detecting a signature of inter-molecular recombination in mtDNA sequences sampled at the population level, inferring a paternal source for the mixed haplotypes. However, interpreting these data is fraught with difficulty, and direct experimental evidence is lacking. Using extreme-high depth mtDNA re-sequencing up to ~1.2 million-fold coverage, we find no evidence that paternal mtDNA haplotypes are transmitted to offspring in humans, thus excluding a simple dilution mechanism for uniparental transmission of mtDNA present in all healthy individuals. Our findings indicate that an active mechanism eliminates paternal mtDNA which likely acts at the molecular level.
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