ArticleScientific reports2015
Multiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Influenza antivirals and animal models.FEBS open bio · 2022Review
- Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19.Frontiers in pharmacology · 2022Review
- Reduning injection combined with western medicine for pneumonia: A protocol for systematic review and meta-analysis.Medicine · 2020Article
- Assessing the Anti-inflammatory Mechanism of Reduning Injection by Network Pharmacology.BioMed research international · 2020Article
- UPLC-QTOF/MSFrontiers in pharmacology · 2018Article
- Combining Chemical Profiling and Network Analysis to Investigate the Pharmacology of Complex Prescriptions in Traditional Chinese Medicine.Scientific reports · 2017Article
- Article
- Integrating Multiscale Modeling with Drug Effects for Cancer Treatment.Cancer informatics · 2015Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ReDuNing injection (RDN) is a patented traditional Chinese medicine, and the components of it were proven to have antiviral and important anti-inflammatory activities. Several reports showed that RDN had potential effects in the treatment of influenza and pneumonia. Though there were several experimental reports about RDN, the experimental results were not enough and complete due to that it was difficult to predict and verify the effect of RDN for a large number of human diseases. Here we employed multiscale model by integrating molecular docking, network pharmacology and the clinical symptoms information of diseases and explored the interaction mechanism of RDN on human diseases. Meanwhile, we analyzed the relation among the drug molecules, target proteins, biological pathways, human diseases and the clinical symptoms about it. Then we predicted potential active ingredients of RDN, the potential target proteins, the key pathways and related diseases. These attempts may offer several new insights to understand the pharmacological properties of RDN and provide benefit for its new clinical applications and research.
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Registered trials
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