ArticleScientific reports2015
Impact of spatial dispersion, evolution, and selection on Ebola Zaire Virus epidemic waves.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
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- Filoviruses: Scientific Gaps and Prototype Pathogen Recommendation.The Journal of infectious diseases · 2023Review
- Molecular adaptations during viral epidemics.EMBO reports · 2022Review
- Ebola virus disease.Nature reviews. Disease primers · 2020Review
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- Filoviruses: Ecology, Molecular Biology, and Evolution.Advances in virus research · 2018Review
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- The 2014 Ebola virus outbreak in West Africa highlights no evidence of rapid evolution or adaptation to humans.Scientific reports · 2016Article
- Molecular epidemiology and phylogeny of Nipah virus infection: A mini review.Asian Pacific journal of tropical medicine · 2016Review
- Driving forces behind the evolution of the Aleutian mink disease parvovirus in the context of intensive farming.Virus evolution · 2016Article
- Evolution of the avian β-defensin and cathelicidin genes.BMC evolutionary biology · 2015Article
- Ebolavirus Evolution: Past and Present.PLoS pathogens · 2015Review
- Local Mutational Pressures in Genomes of Zaire Ebolavirus and Marburg Virus.Advances in bioinformatics · 2015Article
- Phylogenesys and homology modeling in Zika virus epidemic: food for thought.Pathogens and global healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ebola virus Zaire (EBOV) has reemerged in Africa, emphasizing the global importance of this pathogen. Amidst the response to the current epidemic, several gaps in our knowledge of EBOV evolution are evident. Specifically, uncertainty has been raised regarding the potential emergence of more virulent viral variants through amino acid substitutions. Glycoprotein (GP), an essential component of the EBOV genome, is highly variable and a potential site for the occurrence of advantageous mutations. For this study, we reconstructed the evolutionary history of EBOV by analyzing 65 GP sequences from humans and great apes over diverse locations across epidemic waves between 1976 and 2014. We show that, although patterns of spatial dispersion throughout Africa varied, the evolution of the virus has largely been characterized by neutral genetic drift. Therefore, the radical emergence of more transmissible variants is unlikely, a positive finding, which is increasingly important on the verge of vaccine deployment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.