Evidence map›Paper›PMID 25973442›Full record

ArticleTheScientificWorldJournal2015

Control of white spot lesion adjacent to orthodontic bracket with use of fluoride varnish or chlorhexidine gel.

Manuel Restrepo, Diego G Bussaneli, Fabiano Jeremias, Rita C L Cordeiro, Ana C Magalhães, Denise M Palomari Spolidorio, Lourdes Santos-Pinto

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in TheScientificWorldJournal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06403371 (The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06403371 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients: Prospective Randomized Controlled Clinical Trial

TypeinterventionalSponsorKing Abdullah University HospitalRan2023 to 2024Enrolled44ConditionsWhite Spot LesionArmsFluoride varnsh, Normal saline
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Effect of 10% fluoride on the remineralization of dentin in situ.Journal of applied oral science : revista FOB
    Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Chitosan gel prevents the growth ofThe Saudi dental journal · 2021
    Article
  7. Article
  8. Review
  9. Review
  10. Prevention of white spot lesions using three remineralizing agents: An in vitro comparative study.Journal of dental research, dental clinics, dental prospects · 2019
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Manuel RestrepoDepartment of Orthodontics and Pediatric Dentistry, Araraquara School of Dentistry, Universidade Estadual Paulista (Unesp), Rua Humaitá 1680, 14801-903 Araraquara, SP, Brazil.
Diego G BussaneliDepartment of Orthodontics and Pediatric Dentistry, Araraquara School of Dentistry, Universidade Estadual Paulista (Unesp), Rua Humaitá 1680, 14801-903 Araraquara, SP, Brazil.
Fabiano JeremiasDepartment of Orthodontics and Pediatric Dentistry, Araraquara School of Dentistry, Universidade Estadual Paulista (Unesp), Rua Humaitá 1680, 14801-903 Araraquara, SP, Brazil.
Rita C L CordeiroDepartment of Orthodontics and Pediatric Dentistry, Araraquara School of Dentistry, Universidade Estadual Paulista (Unesp), Rua Humaitá 1680, 14801-903 Araraquara, SP, Brazil.
Ana C MagalhãesDepartment of Biological Sciences, Bauru School of Dentistry, University of São Paulo (USP), Alameda Octávio Pinheiro Brisolla 9-75, 17012-191 Bauru, SP, Brazil.
Denise M Palomari SpolidorioDepartment of Physiology and Pathology, Araraquara School of Dentistry, Universidade Estadual Paulista (Unesp), Rua Humaitá 1680, 14801-903 Araraquara, SP, Brazil.
Lourdes Santos-PintoDepartment of Orthodontics and Pediatric Dentistry, Araraquara School of Dentistry, Universidade Estadual Paulista (Unesp), Rua Humaitá 1680, 14801-903 Araraquara, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aims of this study were to compare the effectiveness of fluoride varnish and chlorhexidine gel in controlling white spot lesions (WSLs) adjacent to orthodontic brackets and to compare the ability of Quantitative Light-Induced Fluorescence (QLF) to measure mineral uptake with that of transverse microradiography (TMR). Thirty premolars with artificially induced WSLs were randomly assigned to three groups: (1) two applications of 5% NaF-varnish (F), with one-week interval, (2) two applications of 2% chlorhexidine gel (CHX), with one-week interval, and (3) control (CO), no treatment. QLF was used to measure changes in fluorescence before and after caries induction, 1 week after each application and 1, 2, and 3 months after the last application of F or CHX. TMR was performed to quantify lesion depth and mineral content after caries induction to evaluate the effects of F, CHX, and CO 3 months after the last application of agents. The data were analyzed by repeated measures ANOVA and Tukey's test. All treatments increased the mineral content during the experimental period; however, F induced faster remineralization than CHX. The correlation between QLF and TMR was significantly moderate. Two applications of fluoride varnish or 2% chlorhexidine gel at one-week intervals were effective in controlling WSLs.

Indexed as

ChlorhexidineFluorides, TopicalOrthodontic BracketsDental CariesHumansChlorhexidineFluorides, Topical

Identifiers

PMID25973442
PMCPMC4417997
OpenAlexW1993104602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.