Evidence map›Paper›PMID 25973344›Full record

ReviewCurrent pathobiology reports

Zebrafish Renal Pathology: Emerging Models of Acute Kidney Injury.

Robert A McKee, Rebecca A Wingert

Open access · hybridAbstract readReview
In one paragraph

Review in Current pathobiology reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Silver Nanoparticle-Induced Nephrotoxicity in Zebrafish (International journal of molecular sciences · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Ability ofInternational journal of molecular sciences · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Principles of Zebrafish Nephron Segment Development.Journal of developmental biology · 2023
    Review
  14. SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Reduced α-galactosidase A activity in zebrafish (Molecular genetics and metabolism reports · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert A McKeeDepartment of Biological Sciences, Center for Zebrafish Research, Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556 USA.
Rebecca A WingertDepartment of Biological Sciences, Center for Zebrafish Research, Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556 USA.
University of Notre Dame · US

Funding

Identification of Kidney Regeneration Mechanisms Using the ZebrafishDP2OD008470 · OD · UNIVERSITY OF NOTRE DAME · PI WINGERT, REBECCA ANN · 2011 to 2011
$2.3M
NIH HHS DP2 OD008470
6 · The paper itself

Abstract

The renal system is vital to maintain homeostasis in the body, where the kidneys contain nephron functional units that remove metabolic waste from the bloodstream, regulate fluids, and balance electrolytes. Severe organ damage from toxins or ischemia that occurs abruptly can cause acute kidney injury (AKI) in which there is a rapid, life-threatening loss of these activities. Humans have a limited but poorly understood ability to regenerate damaged nephrons after AKI. However, researchers studying AKI in vertebrate animal models such as mammals, and more recently the zebrafish, have documented robust regeneration within the nephron blood filter and tubule following injury. Further, zebrafish kidneys contain progenitors that create new nephrons after AKI. Here, we review investigations in zebrafish which have established a series of exciting renal pathology paradigms that complement existing AKI models and can be implemented to discover insights into kidney regeneration and the roles of stem cells.

Indexed as

Acute kidney injuryNephronRegenerationRenal progenitorRenal stem cellZebrafish

Identifiers

PMID25973344
PMCPMC4419198
OpenAlexW2147797461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.