ArticleJournal of dental research, dental clinics, dental prospects2015
Effect of Fluoride, Chlorhexidine and Fluoride-chlorhexidine Mouthwashes on Salivary Streptococcus mutans Count and the Prevalence of Oral Side Effects.
Article in Journal of dental research, dental clinics, dental prospects, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Assessment of proteomic salivary biomarkers for diagnosis of early childhood caries: a systematic review.Frontiers in oral health · 2025Pooled it
- Dental caries and periodontal disease among people who use drugs: a systematic review and meta-analysis.BMC oral health · 2020Pooled it
- Efficacy of aloe vera and probiotic mouthwashes vs fluoride mouthwash on Streptococcus mutans in plaque around brackets of orthodontic patients: a randomized clinical trial.The Angle orthodontist · 2023Trial
- Herbal and Alcohol-Free Mouthwashes as Chlorhexidine Alternatives for Preventing Enamel Demineralization in Orthodontic Patients: An In Vitro Study.Dentistry journal · 2026Article
- Expert consensus on the prevention and treatment of enamel demineralization in orthodontic treatment.International journal of oral science · 2025Article
- Propolis mouthwashes efficacy in managing gingivitis and periodontitis: a systematic review of the latest findings.BDJ open · 2025Article
- The Efficacy of Photodynamic Therapy againstActa medica Philippina · 2025Article
- Chlorhexidine in Dentistry: Pharmacology, Uses, and Adverse Effects.International dental journal · 2022Review
- The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application.BioMed research international · 2022Review
- Plant-Derived Substances with Antibacterial, Antioxidant, and Flavoring Potential to Formulate Oral Health Care Products.Biomedicines · 2021Review
- Oral mucosa and Streptococcus mutans count in the saliva. Does graphene oxide nanoparticle mouthwash have a good effect?Caspian journal of internal medicine · 2021Article
- Comparison of the Effect Of 0.2% Chlorhexidine and Xylitol Plus 920 Ppm Fluoride Mouthwashes on Count of Salivary Streptococcus Mutants, a Pilot Study.Journal of dentistry (Shiraz, Iran) · 2018Article
- Antibiofilm and Anti-Inflammatory Activities ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Article
- Efficacy of Four Fluoride Mouth Rinses onJournal of clinical and diagnostic research : JCDR · 2016Article
- Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials.Materials (Basel, Switzerland) · 2016Article
- Comparing the Effectiveness of Topical Fluoride and Povidone Iodine with Topical Fluoride Alone for the Prevention of Dental Caries among Children: A Systematic Review and Meta-analysis.International journal of clinical pediatric dentistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims. Streptococcus mutans is the main pathogenic agent involved in dental caries, and may be eliminated using mouthwashes. The objective of this study was to compare the effects of fluoride, chlorhexidine, and fluoride-chlorhexidine mouthwashes on salivary S. mutans count after two weeks of use and determine the prevalence of their side effects on the oral mucosa. Materials and methods. In this clinical trial, 120 12-14 year-old students were selected and divided into three groups. Each group was given one of fluoride, chlorhexidine, or fluoride-chlorhexidine mouthwashes. They were asked to use it twice a day for two weeks. Salivary samples were collected at baseline and after two weeks. Data were analyzed by Wilcoxon and Kruskal-Wallis tests. Results. In all the study groups, there were statistically significant reductions in salivary S. mutans counts two weeks after using the mouthwashes (P < 0.05). In addition, fluoride-chlorhexidine mouthwash had a significant effect on the reduction of S. mutans count in comparison with fluoride alone. The prevalence of oral side effects in fluoride-chlorhexidine mouth-wash was more than 90%. Conclusion. Adding fluoride to chlorhexidine mouthwash can significantly decrease salivary S. mutans count after two weeks. Fluoride-chlorhexidine has the highest rate of oral side effects between the evaluated mouthwash compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.