Evidence map›Paper›PMID 25973095›Full record

ArticleInternational journal of clinical and experimental pathology2015

Melanocortinergic circuits from medial vestibular nuclei to the kidney defined by transneuronal transport of pseudorabies virus.

Dan Shang, Jun Xiong, Hong-Bing Xiang, Yan Hao, Jiu-Hong Liu

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Changes in body composition in unilateral vestibular hypofunction: relationships between bioelectrical impedance analysis and neuro-otological parameters.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dan ShangDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology University No. 1277 Jiefang Ave, Wuhan 430022, People's Republic of China.
Jun XiongHepatobiliary Surgery Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology University No. 1277 Jiefang Ave, Wuhan 430022, People's Republic of China.
Hong-Bing XiangDepartment of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology No. 1095 Jiefang Road, Wuhan 430030, People's Republic of China.
Yan HaoDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology No. 1095 Jiefang Road, Wuhan 430030, People's Republic of China.
Jiu-Hong LiuDepartment of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology No. 1095 Jiefang Road, Wuhan 430030, People's Republic of China.
Tongji Hospital · CNUnion Hospital · CN

Funding

ResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0M
NIH HHS NIH P40 OD010996NIH HHS P40 OD010996
6 · The paper itself

Abstract

This study was designed to assess whether MC4R signaling existed in vestibular nuclei modulated the activity of kidney by a virally mediated transsynaptic tracing study. Pseudorabies virus (PRV)-614 was injected into the kidney in adult male MC4R-green fluorescent protein (GFP) transgenic mice (n = 5). After a survival time of 5 days, the mice were assigned to humanely sacrifice, and the brainstem were removed and sectioned, and processed for PRV-614 visualization. The neurochemical phenotype of MC4R-GFP-positive neurons was identified using fluorescence immunocytochemical labeling. PRV-614/MC4R-GFP dual labeled neurons were detected in medial vestibular nuclei. Our findings support the hypothesis that there exist melanocortinergic circuits from medial vestibular nuclei to the kidney.

Indexed as

AnimalsGreen Fluorescent ProteinsHerpesvirus 1, SuidKidneyMaleMelanocortinsMiceMice, TransgenicNeural PathwaysNeuronal Tract-TracersNeuronsSpinal CordVestibular NucleiGreen Fluorescent ProteinsMelanocortinsNeuronal Tract-TracerskidneyMelanocortin-4 receptorpseudorabies virustranssynaptic tracingVestibular nuclei

Identifiers

PMID25973095
PMCPMC4396262
OpenAlexW232463488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.