ArticleInternational journal of clinical and experimental pathology2015
Galectin-1 reduction and changes in T regulatory cells may play crucial roles in patients with unexplained recurrent spontaneous abortion.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- The β-hCG-TNF-α-T cell axis in threatened abortion: unraveling the pathogenic cascade from aberrant glycosylation to inflammatory demise.Frontiers in immunology · 2026Review
- Correlation between Lactobacillus of Vaginal Microbiota and the Pregnancy Outcomes for Patients Experiencing Recurrent Miscarriage.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- LYN and CYBB are pivotal immune and inflammatory genes as diagnostic biomarkers in recurrent spontaneous abortion.Frontiers in immunology · 2025Article
- Galectins in Equine Placental Disease.Veterinary sciences · 2023Article
- Evaluation of Th17 and Treg cytokines in patients with unexplained recurrent pregnancy loss.Journal of clinical and translational research · 2022Article
- Galectins in Early Pregnancy and Pregnancy-Associated Pathologies.International journal of molecular sciences · 2021Review
- Effect of low-molecular-weight heparins on anti-Xa peak levels and adverse reactions in Chinese patients with recurrent spontaneous abortion: a single-center, observational study.BMC pregnancy and childbirth · 2021Observational
- Galectin-1 expression in the serum and placenta of pregnant women with fetal growth restriction and its significance.BMC pregnancy and childbirth · 2021Article
- DNA Methylation and Recurrent Pregnancy Loss: A Mysterious Compass?Frontiers in immunology · 2021Review
- Endometrial Immune Dysfunction in Recurrent Pregnancy Loss.International journal of molecular sciences · 2019Review
- Immunological Basis for Recurrent Fetal Loss and Pregnancy Complications.Annual review of pathology · 2019Review
- [The involvement of galectin-1 in implantation and pregnancy maintenance at the maternal-fetal interface].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2017Article
- Association of miR-34a-3p/5p, miR-141-3p/5p, and miR-24 in Decidual Natural Killer Cells with Unexplained Recurrent Spontaneous Abortion.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the changes of Galectin-1 and T-lymphocyte phenotypes in unexplained recurrent spontaneous abortion (URSA). Totally 60 participants were recruited and divided into 3 groups in average: pregnant patients with URSA (URSA group), normal early pregnant women with induced abortion (IA group) and normal non-pregnant women (control group). After the tissue and blood sample were collected, Galectin-1 was measured using enzyme-linked immunosorbent assay. Then the proportion of T regulatory cells was determined by flow cytometry. The expression levels of Galectin-1 in IA group and URSA group was significantly higher than that in the control group (24.30 ± 3.06 and 6.23 ± 2.41 vs. 1.30 ± 0.66, P < 0.05). Besides, the expression level of Galectin-1 in URSA group was lower than that in IA group (P < 0.05). The percentage of CD4(+)CD25(+)Foxp3(+) Tregs was lower in URSA group than IA group (0.77 ± 0.31 vs. 1.00 ± 0.35, P < 0.05) and the ratio of CD4(+)CD25(+)Foxp3(+)/CD4(+) in URSA group was also obviously lower than that in IA and control group (P < 0.05). Galectin-1 and CD4(+)CD25(+)Foxp3(+) may play essential roles in maintaining a normal pregnancy and their reduction may involve in the pathogenesis of URSA.
Indexed as
Identifiers
25973091PMC4396310W2440828531What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.