Evidence map›Paper›PMID 25973079›Full record

ArticleInternational journal of clinical and experimental pathology2015

Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women.

Tiziana Grassi, Angelo Calcagno, Stefania Marzinotto, Ambrogio P Londero, Maria Orsaria, Gioia N Canciani, Carlo Alberto Beltrami, Diego Marchesoni, Laura Mariuzzi

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In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Tiziana GrassiClinic of Obstetrics and Gynecology, University of Udine 33100 Udine, Italy.
Angelo CalcagnoClinic of Obstetrics and Gynecology, University of Udine 33100 Udine, Italy.
Stefania MarzinottoInstitute of Pathology, University of Udine 33100 Udine, Italy.
Ambrogio P LonderoClinic of Obstetrics and Gynecology, University of Udine 33100 Udine, Italy ; Unit of Obstetrics and Gynecology, S. Polo's Hopital 34074 Monfalcone (GO), Italy.
Maria OrsariaInstitute of Pathology, University of Udine 33100 Udine, Italy.
Gioia N CancianiNorwich Medical School, University of East Anglia Norwich, NR4 7TJ, United Kingdom.
Carlo Alberto BeltramiInstitute of Pathology, University of Udine 33100 Udine, Italy.
Diego MarchesoniClinic of Obstetrics and Gynecology, University of Udine 33100 Udine, Italy.
Laura MariuzziInstitute of Pathology, University of Udine 33100 Udine, Italy.
University of Udine · ITUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo test the immunohistochemical staining pattern of some mismatch repair (MMR) system proteins in endometriotic tissue (ET) and eutopic endometrium.

methodsThis was a retrospective study conducted at the Pathology and Obstetrics and Gynecology Departments of the Udine University Hospital. We analyzed 528 samples obtained from 246 patients affected by endometriosis and 71 samples from 71 patients with normal endometrium. A tissue microarray model was used to analyze the immunohistochemical expression of MMR system proteins.

resultsSignificant loss of MMR proteins was found in the stromal component of ETs. We found MSH2 to be expressed at a higher level than any other MMR system proteins in eutopic endometrium and ETs, to be significantly correlated to Ki-67 expression in both stromal and glandular components of ETs, and to be expressed at a significantly higher level in ETs than in eutopic endometrium. When considering the subgroup of endometriosis with high recurrence rate and glandular cytoplasmic staining for aurora A kinase, we found MMR proteins expressed at a significantly higher level in these ETs than in other ETs and eutopic endometrium of unaffected women.

conclusionsWe found significant loss of MMR proteins (known to be associated with microsatellite instability) in the stromal component of ETs. The group of ETs with glandular cytoplasmic staining for aurora A kinase had higher MMR protein expression, suggesting an increased activity of this system. Our result suggests a novel role of increased MSH2 expression in cellular proliferation of endometriosis.

Indexed as

DNA Mismatch RepairAurora Kinase ABiomarkersCell ProliferationEndometriosisEndometriumFemaleHospitals, UniversityHumansImmunohistochemistryItalyKi-67 AntigenMutS Homolog 2 ProteinRegistriesRetrospective StudiesSignal TransductionAURKA protein, humanAurora Kinase ABiomarkersKi-67 AntigenMSH2 protein, humanMutS Homolog 2 Proteinaurora A kinaseEndometriosismicrosatellite instabilitymismatch repair system proteinsMLH1MSH2MSH6PMS2

Identifiers

PMID25973079
PMCPMC4396318
OpenAlexW2400345591

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.