ArticleInternational journal of clinical and experimental pathology2015
Hyperbaric oxygenation promotes neural stem cell proliferation and protects the learning and memory ability in neonatal hypoxic-ischemic brain damage.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2016Pooled it
- Hyperbaric oxygen treatment for infants: retrospective analysis of 54 patients treated in two tertiary care centres.Diving and hyperbaric medicine · 2024Article
- Hyperbaric oxygen therapy for poststroke insomnia: a systematic review and meta-analysis protocol.BMJ open · 2024Article
- Hypoxic ischemic encephalopathy (HIE).Frontiers in neurology · 2024Review
- Hyperbaric oxygen therapy as a neuromodulatory technique: a review of the recent evidence.Frontiers in neurology · 2024Review
- Hyperbaric Oxygenation Prevents Loss of Immature Neurons in the Adult Hippocampal Dentate Gyrus Following Brain Injury.International journal of molecular sciences · 2023Article
- Nanoparticle and Stem Cell Combination Therapy for the Management of Stroke.Current pharmaceutical design · 2023Article
- Hyperbaric Oxygen Treatment-From Mechanisms to Cognitive Improvement.Biomolecules · 2021Review
- Effects of oxygen generating scaffolds on cell survival and functional recovery following acute spinal cord injury in rats.Journal of materials science. Materials in medicine · 2020Article
- Review
- The Hyperoxic-Hypoxic Paradox.Biomolecules · 2020Review
- COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation.BMC neuroscience · 2020Article
- High oxygen preservation hydrogels to augment cell survival under hypoxic condition.Acta biomaterialia · 2020Article
- HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/β-Catenin and BMP2 Signaling Pathways.Cell transplantation · 2019Article
- A Dual Role for Hyperbaric Oxygen in Stroke Neuroprotection: Preconditioning of the Brain and Stem Cells.Conditioning medicine · 2018Article
- Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency.Physiological reports · 2018Article
- Article
- Hyperbaric Oxygenation Protects Against Ischemia-Reperfusion Injury in Transplanted Rat Kidneys by Triggering Autophagy and Inhibiting Inflammatory Response.Annals of transplantation · 2017Article
- Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy.Open medicine (Warsaw, Poland) · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of our study was to evaluate whether hyperbaric oxygenation (HBO) was an effective therapy for neonatal hypoxic ischemic brain damage (HIBD). Seven-day-old rat pups were divided into 3 groups: sham, hypoxia-ischemia (HI) control and HI-HBO group. HBO was administered for HI rats daily. The pathologic changes in brain tissues were observed by hematoxylin-eosin (H-E) staining. The immunohistochemical staining was applied to detect the Nestin and 5-bromo-2-deoxyuridine (BrdU) positive cells in hippocampal dentate gyrus region. The learning and memory function of rats was examined by Morris water maze. The HI rats showed obvious pathologic changes accompanied by levels decreasing and disorder arrangement of pyramidal cells, glial cells proliferation in postoperative, and nerve nuclei broken, while pathologic changes of rats in sham group was approximate to that in the HI + HBO group that was opposite to the HI group. Compared with the sham group, the Nestin and BrdU positive cells in HBO + HI group at different time points increased significantly (P < 0.01). Learning and memory function of rats in HI group was poor compared with the sham/HI + HBO group (P < 0.01), while that in HI + HBO group was approximate to that in sham group (P > 0.05). HBO treatment improved the learning and memory ability of the HI rats. HBO therapy may be effective for neonatal HIBD treatment.
Indexed as
Identifiers
25973064PMC4396307W249133617What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.