ArticleInternational journal of clinical and experimental pathology2015
SOX14 promotes proliferation and invasion of cervical cancer cells through Wnt/β-catenin pathway.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn's disease.Nature genetics · 2026Article
- Genomic and transcriptomic analysis of cutaneous squamous cell carcinoma arising in immunocompetent and immunosuppressed patients.Oral oncology · 2024Article
- Clinical Significance of SOX10 Expression in Human Pathology.Current issues in molecular biology · 2023Review
- Blood-based DNA methylation in advanced Nasopharyngeal Carcinoma exhibited distinct CpG methylation signature.Scientific reports · 2023Article
- Development of anMolecular therapy. Methods & clinical development · 2023Article
- Offspring epigenetic markers at birth related to gestational BMI predict offspring BMI-trajectories from infancy to 26 years.Obesity science & practice · 2023Review
- Joint analysis of WES and RNA-Seq identify signature genes related to metastasis in prostate cancer.Journal of cellular and molecular medicine · 2023Article
- Bioinformatics analysis of SOXF family genes reveals potential regulatory mechanism and diagnostic value in cancers.Annals of translational medicine · 2022Article
- Functional New Transcription Factors (TFs) Associated with Cervical Cancer.Journal of healthcare engineering · 2022Article
- Tumor DNA Methylation Profiles Enable Diagnosis, Prognosis Prediction, and Screening for Cervical Cancer.International journal of general medicine · 2022Article
- SOX14 hypermethylation as a tumour biomarker in cervical cancer.BMC cancer · 2021Article
- APMAP Promotes Epithelial-Mesenchymal Transition and Metastasis of Cervical Cancer Cells by Activating the Wnt/β-catenin Pathway.Journal of Cancer · 2021Article
- Identification and External Validation of a Transcription Factor-Related Prognostic Signature in Pediatric Neuroblastoma.Journal of oncology · 2021Article
- KIF23 activated Wnt/β-catenin signaling pathway through direct interaction with Amer1 in gastric cancer.Aging · 2020Article
- Gefitinib suppresses cervical cancer progression by inhibiting cell cycle progression and epithelial-mesenchymal transition.Experimental and therapeutic medicine · 2019Article
- Article
- Wnt signaling in cervical cancer?Journal of Cancer · 2018Review
- 'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling.British journal of pharmacology · 2017Review
- Sulfiredoxin May Promote Cervical Cancer Metastasis via Wnt/β-Catenin Signaling Pathway.International journal of molecular sciences · 2017Article
- SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SOX14 is a member of the SOXB2 subgroup of transcription factors implicated in neural development. Although SOX14 expression profile and function during development was revealed in various animal model systems, the role of this gene during tumor progression is totally unknown. In this study, the expression of SOX14 increases in four cervical cancer cell lines (HeLa, Caski, HT-3 and SiHa) as revealed by real-time PCR and Western blot analyses. Through knocking down or overexpressing SOX14 in SiHa and HeLa cells, the expression level of SOX14 was found to be positively related to cell proliferation and invasion in vitro. Moreover, the TOP-Flash reporter assay and Western blot for β-catenin genes of the Wnt/β-catenin pathway, indicated that SOX14 significantly activated Wnt/β-catenin signaling. Further study showed that the blockage of Wnt/β-catenin pathway by knocking down β-catenin resulted in a significant inhibition of cell proliferation and invasion capacity induced by SOX14. To summarize, these results demonstrate that SOX14 can promote proliferation and invasion capacity of cervical cancer cells by activating the Wnt/β-catenin pathway.
Indexed as
Identifiers
25973056PMC4396331W239347600What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.