Evidence map›Paper›PMID 25973046›Full record

ArticleInternational journal of clinical and experimental pathology2015

CD317 is over-expressed in B-cell chronic lymphocytic leukemia, but not B-cell acute lymphoblastic leukemia.

Shunyou Gong, Ebenezer S Osei, David Kaplan, Youhai H Chen, Howard Meyerson

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Review
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  8. Article
  9. CD317 Promotes the survival of cancer cells through apoptosis-inducing factor.Journal of experimental & clinical cancer research : CR · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shunyou GongDepartment of Pathology, University Hospitals Case Medical Center, Case Western Reserve University Cleveland 44106, Ohio, USA ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Philadelphia 19104, PA, USA.
Ebenezer S OseiDepartment of Pathology, University Hospitals Case Medical Center, Case Western Reserve University Cleveland 44106, Ohio, USA.
David KaplanDepartment of Pathology, University Hospitals Case Medical Center, Case Western Reserve University Cleveland 44106, Ohio, USA.
Youhai H ChenDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Philadelphia 19104, PA, USA.
Howard MeyersonDepartment of Pathology, University Hospitals Case Medical Center, Case Western Reserve University Cleveland 44106, Ohio, USA.
University Hospitals of Cleveland · USUniversity of Pennsylvania · US

Funding

Autoimmune Encephalomyelitis and c-RelR01AI050059 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHEN, YOUHAI H · 2001 to 2016
$4.4M
Autoimmune encephalomyelitis and c-RelR56AI050059 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHEN, YOUHAI H · 2011 to 2011
$320k
NIAID NIH HHS AI-050059NIAID NIH HHS R01 AI050059NIAID NIH HHS R56 AI050059
6 · The paper itself

Abstract

CD317 was first identified as a multiple myeloma-associated antigen. Here we report the expression of CD317 in normal B cells and B-cell malignancies. In normal bone marrow, CD317 demonstrates a biphasic expression pattern, with higher expression on stage 1 and stage 3 hematogones, but not on stage 2 hematogones. CD317 is over-expressed in B-cell chronic lymphocytic leukemia, and appears associated with negative CD38 expression. Moreover, CD317 is barely detectable in B-cell acute lymphoblastic leukemia. Our results suggest that CD317 expression might be of prognostic significance for B-CLL, and CD317 could be used as a new marker for minimal residual disease detection in B-ALL.

Indexed as

Acute DiseaseAntigens, CDBiomarkers, TumorBone Marrow Stromal Antigen 2ChildChild, PreschoolFemaleFlow CytometryGPI-Linked ProteinsHumansInfantLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedPrecursor B-Cell Lymphoblastic Leukemia-LymphomaAntigens, CDBiomarkers, TumorBone Marrow Stromal Antigen 2BST2 protein, humanGPI-Linked Proteinsacute lymphoblastic leukemiaB lymphocytesCD317chronic lymphocytic leukemia

Identifiers

PMID25973046
PMCPMC4396245
OpenAlexW217233525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.