ArticleCognitive neurodynamics2015
Control of absence seizures induced by the pathways connected to SRN in corticothalamic system.
Article in Cognitive neurodynamics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 34 citations in OpenAlex.
- The active role of non-synaptic electromagnetic induction in modulating absence epilepsy: a kinetic modeling study.Biological cybernetics · 2026Article
- Striatum is the potential target for treating absence epilepsy: a theoretical evidence.Cognitive neurodynamics · 2024Article
- Dynamic effect of electromagnetic induction on epileptic waveform.BMC neuroscience · 2022Article
- The inhibition mechanism of epilepsy disease in a computational model.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- The therapeutic mechanism of epilepsy seizures in different target areas: Research on a theoretical model.Technology and health care : official journal of the European Society for Engineering and Medicine · 2021Article
- Poor mother-offspring relationships in rats with Cacna1a mutation.Experimental animals · 2020Article
- Regulation and control roles of the basal ganglia in the development of absence epileptiform activities.Cognitive neurodynamics · 2020Article
- The effect of external voltage stimulation on absence seizures.Technology and health care : official journal of the European Society for Engineering and Medicine · 2020Article
- Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation.Neural plasticity · 2020Article
- The generation mechanism of spike-and-slow wave discharges appearing on thalamic relay nuclei.Scientific reports · 2018Article
- Controlling mechanism of absence seizures by deep brain stimulus applied on subthalamic nucleus.Cognitive neurodynamics · 2018Article
- Control of Absence Seizures by the Thalamic Feed-Forward Inhibition.Frontiers in computational neuroscience · 2017Article
- Disinhibition-Induced Delayed Onset of Epileptic Spike-Wave Discharges in a Five Variable Model of Cortex and Thalamus.Frontiers in computational neuroscience · 2016Article
- Critical Roles of the Direct GABAergic Pallido-cortical Pathway in Controlling Absence Seizures.PLoS computational biology · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The cerebral cortex, thalamus and basal ganglia together form an important network in the brain, which is closely related to several nerve diseases, such as parkinson disease, epilepsy seizure and so on. Absence seizure can be characterized by 2-4 Hz oscillatory activity, and it can be induced by abnormal interactions between the cerebral cortex and thalamus. Many experimental results have also shown that basal ganglia are a key neural structure, which closely links the corticothalamic system in the brain. Presently, we use a corticothalamic-basal ganglia model to study which pathways in corticothalamic system can induce absence seizures and how these oscillatory activities can be controlled by projections from the substantia nigra pars reticulata (SNr) to the thalamic reticular nucleus (TRN) or the specific relay nuclei (SRN) of the thalamus. By tuning the projection strength of the pathway "Excitatory pyramidal cortex-SRN", "SRN-Excitatory pyramidal cortex" and "SRN-TRN" respectively, different firing states including absence seizures can appear. This indicates that absence seizures can be induced by tuning the connection strength of the considered pathway. In addition, typical absence epilepsy seizure state "spike-and-slow wave discharges" can be controlled by adjusting the activation level of the SNr as the pathways SNr-SRN and SNr-TRN open independently or together. Our results emphasize the importance of basal ganglia in controlling absence seizures in the corticothalamic system, and can provide a potential idea for the clinical treatment.
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