ArticleFrontiers in neurology2015
DNA methylation perturbations in genes involved in polyunsaturated Fatty Acid biosynthesis associated with depression and suicide risk.
Article in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 72 citations in OpenAlex.
- The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk.Molecular psychiatry · 2024Review
- Molecular Changes Associated with Suicide.International journal of molecular sciences · 2023Review
- The Role of Omega-3 Fatty Acids in the Treatment of Depression in Children and Adolescents: A Literature Review.Cureus · 2023Review
- Review
- DNA Methylation in Depression and Depressive-Like Phenotype: Biomarker or Target of Pharmacological Intervention?Current neuropharmacology · 2022Review
- The Advent of Nutrigenomics: A Narrative Review with an Emphasis on Psychological Disorders.Preventive nutrition and food science · 2022Review
- DNA methylation of tumour necrosis factor (TNF) alpha gene is associated with specific blood fatty acid levels in a gender-specific manner.Molecular genetics & genomic medicine · 2021Article
- Targeting DNA Methylation in the Adult Brain through Diet.Nutrients · 2021Review
- Role of Long Chain Fatty Acids in Developmental Programming in Ruminants.Animals : an open access journal from MDPI · 2021Review
- Serum Fatty Acid Latent Classes Are Associated With Suicide in a Large Military Personnel Sample.The Journal of clinical psychiatry · 2021Article
- Polyunsaturated fatty acid biosynthesis pathway and genetics. implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19Prostaglandins, leukotrienes, and essential fatty acids · 2020Review
- A Brain-Centric Model of Suicidal Behavior.The American journal of psychiatry · 2020Article
- Supplemental Herbal Choline Increases 5-hmC DNA on Whole Blood from Pregnant Ewes and Offspring.Animals : an open access journal from MDPI · 2020Article
- Lipids and Suicide Risk.Current topics in behavioral neurosciences · 2020Article
- The Role of Epigenetic Dysregulation in Suicidal Behaviors.Current topics in behavioral neurosciences · 2020Article
- Fatty Acids in Ten Species of Fish Commonly Consumed by the Anishinaabe of the Upper Great Lakes.Journal of Great Lakes research · 2018Article
- Neuropathology of suicide: recent findings and future directions.Molecular psychiatry · 2017Review
- Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk.Current psychiatry reports · 2017Review
- Lipid correlates of antidepressant response to omega-3 polyunsaturated fatty acid supplementation: A pilot study.Prostaglandins, leukotrienes, and essential fatty acids · 2017Article
- Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application.Progress in lipid research · 2017Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyunsaturated fatty acid (PUFA) status has been associated with neuropsychiatric disorders, including depression and risk of suicide. Long-chain PUFAs (LC-PUFAs) are obtained in the diet or produced by sequential desaturation and elongation of shorter-chain precursor fatty acids linoleic acid (LA, 18:2n-6) and α-linolenic acid (ALA, 18:3n-3). We compared DNA methylation patterns in genes involved in LC-PUFA biosynthesis in major depressive disorder (MDD) with (n = 22) and without (n = 39) history of suicide attempt, and age- and sex-matched healthy volunteers (n = 59). Plasma levels of selected PUFAs along the LC-PUFA biosynthesis pathway were determined by transesterification and gas chromatography. CpG methylation levels for the main human LC-PUFA biosynthetic genes, fatty acid desaturases 1 (Fads1) and 2 (Fads2), and elongation of very long-chain fatty acids protein 5 (Elovl5), were assayed by bisulfite pyrosequencing. Associations between PUFA levels and diagnosis or suicide attempt status did not survive correction for multiple testing. However, MDD diagnosis and suicide attempts were significantly associated with DNA methylation in Elovl5 gene regulatory regions. Also the relative roles of PUFA levels and DNA methylation with respect to diagnostic and suicide attempt status were determined by least absolute shrinkage and selection operator logistic regression analyses. We found that PUFA associations with suicide attempt status were explained by effects of Elovl5 DNA methylation within the regulatory regions. The observed link between plasma PUFA levels, DNA methylation, and suicide risk may have implications for modulation of disease-associated epigenetic marks by nutritional intervention.
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