ReviewFrontiers in human neuroscience2015
Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis.
Review in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Probing the linguistic cerebellum: a qualitative review of the effects of cerebellar neurostimulation on language processing.Frontiers in psychiatry · 2026Pooled it
- Cognitive and Linguistic Benefits of Aerobic Exercise: A State-of-the-Art Systematic Review of the Stroke Literature.Frontiers in rehabilitation sciences · 2021Pooled it
- Transcranial direct current stimulation (tDCS) for improving aphasia in adults with aphasia after stroke.The Cochrane database of systematic reviews · 2019Pooled it
- Effectiveness of noninvasive brain stimulation in the treatment of anxiety disorders: a meta-analysis of sham or behaviour-controlled studies.Journal of psychiatry & neuroscience : JPNPooled it
- rTMS Modulates Static and Dynamic Brain Functional Networks in Children with Autism Spectrum Disorder: An EEG Microstate Study.Brain topography · 2026Trial
- The Effect of rTMS over the Different Targets on Language Recovery in Stroke Patients with Global Aphasia: A Randomized Sham-Controlled Study.BioMed research international · 2019Trial
- Mechanisms associated with tDCS as an adjuvant to shortened phonomotor treatment in chronic post-stroke aphasia.Neuroimage. Reports · 2026Article
- Advances in Neuromodulation Techniques for Aphasia Rehabilitation: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Semantic and Phonological Abilities Inform Efficacy of Transcranial Magnetic Stimulation on Sustained Aphasia Treatment Outcomes.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Remapping and Reconnecting the Language Network after Stroke.Brain sciences · 2024Review
- Clinical implementation, barriers, and unmet needs of rTMS and neuro-navigation systems in stroke rehabilitation: a nationwide survey in South Korea.Frontiers in neurology · 2024Article
- Targeted neurorehabilitation strategies in post-stroke aphasia.Restorative neurology and neuroscience · 2023Review
- Functional Network Changes After High-Frequency rTMS Over the Most Activated Speech-Related Area Combined With Speech Therapy in Chronic Stroke With Non-fluent Aphasia.Frontiers in neurology · 2022Article
- Neuromodulatory effects of transcranial magnetic stimulation on language performance in healthy participants: Systematic review and meta-analysis.Frontiers in human neuroscience · 2022Article
- Functional Remodeling Associated With Language Recovery After Repetitive Transcranial Magnetic Stimulation in Chronic Aphasic Stroke.Frontiers in neurology · 2022Article
- Functional Magnetic Resonance Imaging of Language Following Constraint-Induced Aphasia Therapy Primed with Intermittent Theta Burst Stimulation in 13 Patients with Post-Stroke Aphasia.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Cognitive rehabilitation interventions after stroke: protocol for a systematic review and meta-analysis of randomized controlled trials.Systematic reviews · 2021Article
- High-Frequency rTMS Improves Cognitive Function by Regulating Synaptic Plasticity in Cerebral Ischemic Rats.Neurochemical research · 2021Article
- Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury.Military Medical Research · 2020Review
- Neuromodulation in post-stroke aphasia treatment.Current physical medicine and rehabilitation reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic communication impairment is common after stroke, and conventional speech and language therapy (SLT) strategies have limited effectiveness in post-stroke aphasia. Neurorehabilitation with non-invasive brain stimulation techniques (NIBS)-particularly repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS)-may enhance the effects of SLT in selected patients. Applying inhibitory NIBS to specific homologous language regions may induce neural reorganization and reduce interhemispheric competition. This mini review highlights randomized controlled trials (RCTs) and randomized cross-over trials using low-frequency rTMS or cathodal tDCS over the non-lesioned non-language dominant hemisphere and performs an exploratory meta-analysis of those trials considered combinable. Using a random-effects model, a meta-analysis of nine eligible trials involving 215 participants showed a significant mean effect size of 0.51 (95% CI = 0.24-0.79) for the main outcome "accuracy of naming" in language assessment. No heterogeneity was observed (I (2) = 0%). More multicenter RCTs with larger populations and homogenous intervention protocols are required to confirm these and the longer-term effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.