ArticleFrontiers in neural circuits2015
Spatial organization of excitatory synaptic inputs to layer 4 neurons in mouse primary auditory cortex.
Article in Frontiers in neural circuits, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Article
- Article
- Patchy harmonic functional connectivity of the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Alpha-2 nicotinic acetylcholine receptors regulate spectral integration in auditory cortex.Frontiers in neural circuits · 2024Article
- Article
- Development of Auditory Cortex Circuits.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Laser-Induced Apoptosis of Corticothalamic Neurons in Layer VI of Auditory Cortex Impact on Cortical Frequency Processing.Frontiers in neural circuits · 2021Article
- Modeling and MEG evidence of early consonance processing in auditory cortex.PLoS computational biology · 2019Article
- Thalamocortical and Intracortical Inputs Differentiate Layer-Specific Mouse Auditory Corticocollicular Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity.Cell reports · 2018Article
- A metaplasticity view of the interaction between homeostatic and Hebbian plasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- NCAM Regulates Inhibition and Excitability in Layer 2/3 Pyramidal Cells of Anterior Cingulate Cortex.Frontiers in neural circuits · 2017Article
- Thalamocortical-auditory network alterations following cuprizone-induced demyelination.Journal of neuroinflammation · 2016Article
- Spectral breadth and laminar distribution of thalamocortical inputs to A1.Journal of neurophysiology · 2016Article
- Mapping Auditory Synaptic Circuits with Photostimulation of Caged Glutamate.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Layer 4 (L4) of primary auditory cortex (A1) receives a tonotopically organized projection from the medial geniculate nucleus of the thalamus. However, individual neurons in A1 respond to a wider range of sound frequencies than would be predicted by their thalamic input, which suggests the existence of cross-frequency intracortical networks. We used laser scanning photostimulation and uncaging of glutamate in brain slices of mouse A1 to characterize the spatial organization of intracortical inputs to L4 neurons. Slices were prepared to include the entire tonotopic extent of A1. We find that L4 neurons receive local vertically organized (columnar) excitation from layers 2 through 6 (L6) and horizontally organized excitation primarily from L4 and L6 neurons in regions centered ~300-500 μm caudal and/or rostral to the cell. Excitatory horizontal synaptic connections from layers 2 and 3 were sparse. The origins of horizontal projections from L4 and L6 correspond to regions in the tonotopic map that are approximately an octave away from the target cell location. Such spatially organized lateral connections may contribute to the detection and processing of auditory objects with specific spectral structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.