ArticleMetabolomics : Official journal of the Metabolomic Society
MarVis-Pathway: integrative and exploratory pathway analysis of non-targeted metabolomics data.
Article in Metabolomics : Official journal of the Metabolomic Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- High-Quality Predicted Metabolite-Pathway Annotations Expand Pathway Coverage and Increase Enriched Pathway Detection Across Metabolomics Datasets.Metabolites · 2026Article
- Exploring the biochemical and biological functions of copper radical oxidases in the vascular wilt phytopathogenApplied and environmental microbiology · 2026Article
- Standardizing Methods for Shoot Metabolomics in Mycorrhizal Plants.Methods in molecular biology (Clifton, N.J.) · 2026Article
- High-Quality Predicted Pathway Annotations Greatly Improve Pathway Enrichment Analysis of Metabolomics Datasets.bioRxiv : the preprint server for biology · 2025Article
- Elicitor Specific Mechanisms of Defence Priming in Oak Seedlings Against Powdery Mildew.Plant, cell & environment · 2025Article
- Unravelling induced resistance in strawberry: distinct metabolomic signatures define cultivar-specific resistance toFrontiers in plant science · 2025Article
- Wounding Triggers Wax Biosynthesis in Arabidopsis Leaves in an Abscisic Acid-Dependent and Jasmonoyl-Isoleucine-Dependent Manner.Plant & cell physiology · 2024Article
- Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens.Plant communications · 2024Article
- N-Hydroxy pipecolic acid methyl ester is involved in Arabidopsis immunity.Journal of experimental botany · 2023Article
- A comprehensive survey of the approaches for pathway analysis using multi-omics data integration.Briefings in bioinformatics · 2022Review
- Survey for Computer-Aided Tools and Databases in Metabolomics.Metabolites · 2022Review
- Plastidic membrane lipids are oxidized by a lipoxygenase inFrontiers in plant science · 2022Article
- A non-targeted metabolomics analysis identifies wound-induced oxylipins inFrontiers in plant science · 2022Article
- Plants Metabolome Study: Emerging Tools and Techniques.Plants (Basel, Switzerland) · 2021Review
- Mycorrhizal symbiosis primes the accumulation of antiherbivore compounds and enhances herbivore mortality in tomato.Journal of experimental botany · 2021Article
- The glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant immunity.The Plant cell · 2021Article
- Lolium perenne apoplast metabolomics for identification of novel metabolites produced by the symbiotic fungus Epichloë festucae.The New phytologist · 2020Article
- Metabolomics: A Way Forward for Crop Improvement.Metabolites · 2019Review
- The glycosyltransferase UGT76E1 significantly contributes to 12-The Journal of biological chemistry · 2019Article
- Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community.Metabolites · 2019Article
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8 authors.
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Abstract
A central aim in the evaluation of non-targeted metabolomics data is the detection of intensity patterns that differ between experimental conditions as well as the identification of the underlying metabolites and their association with metabolic pathways. In this context, the identification of metabolites based on non-targeted mass spectrometry data is a major bottleneck. In many applications, this identification needs to be guided by expert knowledge and interactive tools for exploratory data analysis can significantly support this process. Additionally, the integration of data from other omics platforms, such as DNA microarray-based transcriptomics, can provide valuable hints and thereby facilitate the identification of metabolites via the reconstruction of related metabolic pathways. We here introduce the MarVis-Pathway tool, which allows the user to identify metabolites by annotation of pathways from cross-omics data. The analysis is supported by an extensive framework for pathway enrichment and meta-analysis. The tool allows the mapping of data set features by ID, name, and accurate mass, and can incorporate information from adduct and isotope correction of mass spectrometry data. MarVis-Pathway was integrated in the MarVis-Suite (http://marvis.gobics.de), which features the seamless highly interactive filtering, combination, clustering, and visualization of omics data sets. The functionality of the new software tool is illustrated using combined mass spectrometry and DNA microarray data. This application confirms jasmonate biosynthesis as important metabolic pathway that is upregulated during the wound response of Arabidopsis plants.
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