Evidence map›Paper›PMID 25972744›Full record

ArticleSaudi journal of biological sciences2015

Screening of mitochondrial mutations and insertion-deletion polymorphism in gestational diabetes mellitus in the Asian Indian population.

Imran Ali Khan, Noor Ahmad Shaik, Nagarjuna Pasupuleti, Srinivas Chava, Parveen Jahan, Qurratulain Hasan, Pragna Rao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Multisystem clinicopathologic and genetic analysis of MELAS.Orphanet journal of rare diseases · 2024
    Article
  5. Observational
  6. Mitochondrial Diabetes is Associated with tRNADiabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Gestational Diabetes Mellitus - The Modern Indian Perspective.Indian journal of endocrinology and metabolism
    Review
  15. Genetics of Gestational Diabetes Mellitus - The Indian Perspective.Indian journal of endocrinology and metabolism
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Imran Ali KhanDepartment of Genetics and Molecular Medicine, Kamineni Hospitals, LB Nagar, Hyderabad 500068, India ; Department of Genetics, Vasavi Medical and Research Centre, Lakdikapool, Hyderabad 500004, India ; Department of Genetics and Biotechnology, Osmania University, Tarnaka, Hyderabad 500007, India.
Noor Ahmad ShaikDepartment of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Nagarjuna PasupuletiDepartment of Genetics and Molecular Medicine, Kamineni Hospitals, LB Nagar, Hyderabad 500068, India.
Srinivas ChavaDepartment of Genetics, Vasavi Medical and Research Centre, Lakdikapool, Hyderabad 500004, India.
Parveen JahanDepartment of Genetics and Biotechnology, Osmania University, Tarnaka, Hyderabad 500007, India.
Qurratulain HasanDepartment of Genetics and Molecular Medicine, Kamineni Hospitals, LB Nagar, Hyderabad 500068, India ; Department of Genetics, Vasavi Medical and Research Centre, Lakdikapool, Hyderabad 500004, India.
Pragna RaoDepartment of Biochemistry, Kasturba Medical College, Manipal University, Manipal 576104, Karnataka, India.
Kamineni Hospitals · INKing Abdulaziz University · SAManipal Academy of Higher Education · INOsmania University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study we scrutinized the association between the A8344G/A3243G mutations and a 9-bp deletion polymorphism with gestational diabetes mellitus (GDM) in an Asian Indian population. The A3243G mutation in the mitochondrial tRNA(Leu(UUR)) causes mitochondrial encephalopathy myopathy, lactic acidosis, and stroke-like episodes (MELAS), while the A8344G mutation in tRNA(Lys) causes myoclonus epilepsy with ragged red fibers (MERRF). We screened 140 pregnant women diagnosed with GDM and 140 non-GDM participants for these mutations by PCR-RFLP analysis. Both A3243G and A8344G were associated with GDM (A3243: OR-3.667, 95% CI = 1.001-13.43, p = 0.03; A8344G: OR-11.00, 95% CI = 0.6026-200.8, p = 0.04). Mitochondrial DNA mutations contribute to the development of GDM. Our results conclude that mitochondrial mutations are associated with the GDM women in our population. Thus it is important to screen other mitochondrial mutations in the GDM women.

Indexed as

A3243GA8344GGDMMELASMERRFMitochondria

Identifiers

PMID25972744
PMCPMC4423658
OpenAlexW2046607472

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.