ArticleJournal of neurophysiology2015
Age-related changes of auditory brainstem responses in nonhuman primates.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Physiological, Histological, and Cognitive Characterization of a Rhesus Macaque Model of Presbycusis.bioRxiv : the preprint server for biology · 2026Article
- Effects of Age on Responses of Principal Cells of the Mouse Anteroventral Cochlear Nucleus in Quiet and Noise.eNeuro · 2024Article
- Audiologic characterization using clinical physiological measures: Normative data from macaque monkeys.Hearing research · 2022Article
- Article
- Correlations between cochlear pathophysiology and behavioral measures of temporal and spatial processing in noise exposed macaques.Hearing research · 2021Article
- Auditory and Visual System White Matter Is Differentially Impacted by Normative Aging in Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Auditory Processing Deficits Are Selectively Associated with Medial Temporal Lobe Mnemonic Function and White Matter Integrity in Aging Macaques.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Sex-based Differences in Hearing Loss: Perspectives From Non-clinical Research to Clinical Outcomess.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2020Review
- The local translation ofAging · 2019Article
- The use of nonhuman primates in studies of noise injury and treatment.The Journal of the Acoustical Society of America · 2019Review
- Age-Related Changes in Temporal Processing of Rapidly-Presented Sound Sequences in the Macaque Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Effects of noise overexposure on tone detection in noise in nonhuman primates.Hearing research · 2018Article
- Positive impacts of early auditory training on cortical processing at an older age.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Neural Consequences of Age-Related Hearing Loss.Trends in neurosciences · 2016Review
- Effects of aging on the response of single neurons to amplitude-modulated noise in primary auditory cortex of rhesus macaque.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Nonhuman primates, compared with humans and rodents, have historically been far less used for studies of age-related hearing loss, primarily because of their long life span and high cost of maintenance. Strong similarities in genetics, anatomy, and neurophysiology of the auditory nervous system between humans and monkeys, however, could provide fruitful opportunities to enhance our understanding of hearing loss. The present study used a common, noninvasive technique for testing hearing sensitivity in humans, the auditory brainstem response (ABR), to assess the hearing of 48 rhesus macaques from 6 to 35 yr of age to clicks and tone stimuli between 0.5 and 16.0 kHz. Old monkeys, particularly those above 21.5 yr of age, had missing ABR waveforms at high frequencies. Regression analyses revealed that ABR threshold increased as a function of age at peaks II and IV simultaneously. In the suprathreshold hearing condition (70 dB peak sound pressure level), ABR-based audiograms similarly varied as a function of age such that old monkeys had smaller peak amplitudes and delayed latencies at low, middle, and high frequencies. Peripheral hearing differences remained a major influence associated with age-related changes in audiometric functions of old monkeys at a comparable sensation level across animals. The present findings suggest that hearing loss occurs in old monkeys across a wide range of frequencies and that these deficits increase in severity with age. Parallel to prior studies in monkeys, we found weak effects of sex on hearing, and future investigations are necessary to clarify its role in age-related hearing loss.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.