ArticleJournal of virology2015
Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish.
Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Zebrafish as a Model for Investigating Antiviral Innate Immunity.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Zebrafish (International journal of molecular sciences · 2024Review
- Zebrafish as a model organism for virus disease research: Current status and future directions.Heliyon · 2024Article
- Suppressors of cGAS-STING are downregulated during fin-limb regeneration and aging in aquatic vertebrates.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Transcriptionally distinct B cell profiles in systemic immune tissues and peritoneal cavity of Atlantic salmon (Frontiers in immunology · 2024Article
- Eukaryotic translation elongation factor 1 alpha (eEF1A) inhibitsJournal of virology · 2023Article
- Zebrafish TMEM47 is an effective blocker of IFN production during RNA and DNA virus infection.Journal of virology · 2023Article
- Systems pharmacology dissection of pharmacological mechanisms of Xiaochaihu decoction against human coronavirus.BMC complementary medicine and therapies · 2023Article
- Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth.Chemical science · 2023Article
- Discovery of a photoactivatable dimerized STING agonist based on the benzo[Chemical science · 2023Article
- Susceptibility and Permissivity of Zebrafish (Viruses · 2023Article
- CRISPR/Cas9-Induced Knockout ofBiomolecules · 2023Article
- When herpes simplex virus encephalitis meets antiviral innate immunity.Frontiers in immunology · 2023Review
- Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature.Open biology · 2022Review
- Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world.Journal of neuroinflammation · 2022Review
- Zebrafish: an underutilized tool for discovery in host-microbe interactions.Trends in immunology · 2022Review
- The Emerging Role of STING in Insect Innate Immune Responses and Pathogen Evasion Strategies.Frontiers in immunology · 2022Review
- Goose STING mediates IFN signaling activation against RNA viruses.Frontiers in immunology · 2022Article
- Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production.Developmental cell · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledZebrafish (Danio rerio) is a unique potential model animal for dissecting innate immune signaling. Here we demonstrate that herpes simplex virus 1 (HSV-1) could infect zebrafish at its different developmental stages and trigger the expression of type I interferons (IFNs) as well as interferon-stimulated genes (ISGs) in zebrafish larvae. Silencing of zSTING, but not zMAVS, markedly attenuates the DNA virus-induced antiviral responses. Notably, a conserved serine residue (S373) is essential for the action of zSTING. Unexpectedly, zebrafish cyclic GMP-AMP synthase (cGAS) is dispensable for the STING signaling, whereas zDHX9 and zDDX41 are potential sensors for HSV-1 infection in vivo. Taken together, this proof-of-concept study establishes the zebrafish larva as a feasible model for investigating the cytosolic DNA sensing mechanism, shedding light on the conservation of the STING antiviral signaling pathway. IMPORTANCE: The zebrafish larva provides technical advantages for understanding host-pathogen interactions. In this study, we established the zebrafish larva as a useful model for studying HSV-1 infection. HSV-1 infection triggers strong type I interferon production, which depends on STING expression. In addition, STING-mediated antiviral signaling is conserved in zebrafish. Interestingly, zDHX9 and zDDX41 are indispensable for detecting HSV-1, while cGAS is dispensable. This proof-of-concept study indicates that the zebrafish represents an amenable model for the investigation of cytosolic DNA sensing mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.