ArticleProceedings. Biological sciences2015
Biologically and diagenetically derived peptide modifications in moa collagens.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
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- Count Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler's Documents by EVA Technology and Mass Spectrometry.Analytical chemistry · 2023Article
- Proteomic Characterization of Collagen-Based Animal Glues for Restoration.Journal of proteome research · 2022Article
- Paleoproteomics.Chemical reviews · 2022Review
- Article
- Molecular signatures written in bone proteins of 79 AD victims from Herculaneum and Pompeii.Scientific reports · 2022Article
- Review
- A primer for ZooMS applications in archaeology.Proceedings of the National Academy of Sciences of the United States of America · 2022Review
- Meta-proteomic analysis of the Shandrin mammoth by EVA technology and high-resolution mass spectrometry: what is its gut microbiota telling us?Amino acids · 2021Article
- Assessing the degradation of ancient milk proteins through site-specific deamidation patterns.Scientific reports · 2021Article
- Article
- Ancient protein analysis in archaeology.Science advances · 2021Review
- Proteomic method to extract, concentrate, digest and enrich peptides from fossils with coloured (humic) substances for mass spectrometry analyses.Royal Society open science · 2019Article
- Palaeoproteomic Profiling of Conservation Layers on a 14th Century Italian Wall Painting.Angewandte Chemie (International ed. in English) · 2018Article
- Elucidation of cross-species proteomic effects in human and hominin bone proteome identification through a bioinformatics experiment.BMC evolutionary biology · 2018Article
- Preservation potential of keratin in deep time.PloS one · 2018Article
- Proteomic profiling of archaeological human bone.Royal Society open science · 2017Article
- A fossil protein chimera; difficulties in discriminating dinosaur peptide sequences from modern cross-contamination.Proceedings. Biological sciences · 2017Article
- Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein.Journal of proteome research · 2017Article
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3 authors.
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Abstract
The modifications that occur on proteins in natural environments over time are not well studied, yet characterizing them is vital to correctly interpret sequence data recovered from fossils. The recently extinct moa (Dinornithidae) is an excellent candidate for investigating the preservation of proteins, their post-translational modifications (PTMs) and diagenetic alterations during degradation. Moa protein extracts were analysed using mass spectrometry, and peptides from collagen I, collagen II and collagen V were identified. We also identified biologically derived PTMs (i.e. methylation, di-methylation, alkylation, hydroxylation, fucosylation) on amino acids at locations consistent with extant proteins. In addition to these in vivo modifications, we detected novel modifications that are probably diagenetically derived. These include loss of hydroxylation/glutamic semialdehyde, carboxymethyllysine and peptide backbone cleavage, as well as previously noted deamidation. Moa collagen sequences and modifications provide a baseline by which to evaluate proteomic studies of other fossils, and a framework for defining the molecular relationship of moa to other closely related taxa.
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