Evidence map›Paper›PMID 25972436›Full record

ArticleJournal of the Royal Society, Interface2015

Semi-adaptive response and noise attenuation in bone morphogenetic protein signalling.

Tian Hong, Ernest S Fung, Lei Zhang, Grace Huynh, Edwin S Monuki, Qing Nie

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Tian HongDepartment of Mathematics, University of California, Irvine, CA, USA Center for Complex Biological Systems, University of California, Irvine, CA, USA.
Ernest S FungCenter for Complex Biological Systems, University of California, Irvine, CA, USA Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA.
Lei ZhangBeijing International Center for Mathematical Research, Peking University, Beijing, China.
Grace HuynhDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA.
Edwin S MonukiCenter for Complex Biological Systems, University of California, Irvine, CA, USA Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA emonuki@uci.edu.ORCID http://orcid.org/0000-0001-5130-781X
Qing NieDepartment of Mathematics, University of California, Irvine, CA, USA Center for Complex Biological Systems, University of California, Irvine, CA, USA qnie@uci.edu.
University of California, Irvine · USPeking University · CN

Funding

Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D · 2007 to 2016
$25.1M
Defining an Integrated Signaling Network That Patterns the Craniofacial SkeletonR01DE023050 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI CLOUTHIER, DAVID E., NIE, QING · 2014 to 2018
$3.2M
Stochastic Dynamics and Noise Control in Patterning SystemsR01GM107264 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING, SCHILLING, THOMAS F · 2014 to 2017
$1.3M
The Morphogen and Selector Gene Network in the Dorsal Telencephalic MidlineR01NS064587 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MONUKI, EDWIN S · 2008 to 2011
$1.2M
NIDCR NIH HHS R01 DE023050NIDCR NIH HHS R01DE023050NIGMS NIH HHS P50 GM076516NIGMS NIH HHS P50GM76516NIGMS NIH HHS R01GM107264NINDS NIH HHS R01NS064587
6 · The paper itself

Abstract

Temporal dynamics of morphogen-driven signalling events are critical for proper embryonic development. During development, cells translate extracellular bone morphogenetic protein (BMP) gradients, often subject to noise, into graded intracellular tail-phosphorylated SMAD (TP-SMAD) levels. Using modelling and experimental approaches, we found that BMPs induce TP-SMAD responses in neural precursor cells in a concentration-dependent manner, which are semi-adaptive within a specific intermediate range of BMP concentration. These semi-adaptive TP-SMAD responses involve an intrinsically slow deactivation of BMP receptors, which attenuates noise by prolonging SMAD deactivation time after BMP withdrawal, but increases response time. Interestingly, negative feedback on BMP receptors is also required for semi-adaptation, which benefits both noise attenuation and response time, and therefore balances the trade-off seen with slow BMP receptor deactivation. These results highlight the rich dynamics of SMAD regulation in response to graded BMP concentration, and elucidate general design principles for balancing noise attenuation and activation speed in signalling systems.

Indexed as

Models, BiologicalAnimalsBone Morphogenetic Protein ReceptorsBone Morphogenetic ProteinsCells, CulturedEmbryo, MammalianEmbryonic DevelopmentMiceNeural Stem CellsSignal-To-Noise RatioSignal TransductionSmad ProteinsBone Morphogenetic Protein ReceptorsBone Morphogenetic ProteinsSmad Proteinsactivation timeadaptive responsenegative feedbacknoise attenuationresponse speedSMAD phosphorylation

Identifiers

PMID25972436
PMCPMC4590514
OpenAlexW2278315399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.