Evidence map›Paper›PMID 25972405›Full record

Trial reportClinical and vaccine immunology : CVI2015

Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease.

Rhonda L LaFleur, Steven M Callister, Jennifer C Dant, Terri L Wasmoen, Dean A Jobe, Steven D Lovrich

Open access · diamondAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and vaccine immunology : CVI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rhonda L LaFleurMerck Animal Health, Inc., Elkhorn, Nebraska, USA.
Steven M CallisterGundersen Health System, La Crosse, Wisconsin, USA smcallis@gundersenhealth.org.
Jennifer C DantMerck Animal Health, Inc., Elkhorn, Nebraska, USA.
Terri L WasmoenMerck Animal Health, Inc., Elkhorn, Nebraska, USA.
Dean A JobeGundersen Health System, La Crosse, Wisconsin, USA.
Steven D LovrichGundersen Health System, La Crosse, Wisconsin, USA.
Gundersen Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beagles received placebo or ospA- and ospB-negative Borrelia burgdorferi before a tick challenge. A total of 28 (41%) ticks and skin biopsy specimens from each control dog (n = 10) contained B. burgdorferi. In contrast, 12 (19%) ticks recovered from the vaccine recipients (n = 10) were infected (P = 0.0077), and 5 dogs yielded spirochetes from the skin biopsy specimens (P = 0.0325). In addition, 9 (90%) placebo recipients and 4 (40%) vaccine recipients developed joint abnormalities (P = 0.0573). Therefore, vaccination with the ospA- and ospB-negative spirochete provided significant protection against Lyme disease.

Indexed as

Bacterial VaccinesBorrelia burgdorferiDog DiseasesLyme DiseaseVaccinationAnimalsAntigens, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsDogsLipoproteinsPlacebosTreatment OutcomeVaccines, AttenuatedAntigens, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesLipoproteinsOspA proteinOspB protein, Borrelia burgdorferiPlacebosVaccines, Attenuated

Identifiers

PMID25972405
PMCPMC4478514
OpenAlexW2326559180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.