Evidence map›Paper›PMID 25972288›Full record

Trial reportIndian journal of pediatrics2015

Influence of Vitamin D Receptor Gene Fok1 Polymorphism on Bone Mass Accrual Post Calcium and Vitamin D Supplementation.

Neha Sanwalka, Anuradha Khadilkar, Shashi Chiplonkar, Kavita Khatod, Nikhil Phadke, Vaman Khadilkar

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Indian journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Vitamin D Receptor (Nutrients · 2022
    Pooled it
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  6. Investigation of the Relationship BetweenTurkish journal of haematology : official journal of Turkish Society of Haematology · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Neha SanwalkaDepartment of Nutrition and Biostatistics, NutriCanvas, Mumbai, India.
Anuradha KhadilkarDepartment of Growth and Endocrine, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Old Building Basement, 32, Sassoon Road, Pune, Maharashtra, 411001, India. anuradhavkhadilkar@gmail.com.
Shashi ChiplonkarDepartment of Growth and Endocrine, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Old Building Basement, 32, Sassoon Road, Pune, Maharashtra, 411001, India.
Kavita KhatodDepartment of Molecular Diagnostics, GenePath Diagnostics, Pune, India.
Nikhil PhadkeDepartment of Molecular Diagnostics, GenePath Diagnostics, Pune, India.
Vaman KhadilkarDepartment of Growth and Endocrine, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Old Building Basement, 32, Sassoon Road, Pune, Maharashtra, 411001, India.
Jehangir Hospital · INGenePath Dx (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the association of vitamin D receptor (VDR) gene polymorphisms of the Fok1 locus on bone mass accrual in Indian girls used to a low calcium intake.

methodsAn intervention trial was undertaken in 102 girls aged 8-16 y, attending a state run school in Pune city, India. All girls received 500 mg calcium daily and 30,000 IU of vitamin D3 quarterly for one year. Dietary calcium intake was evaluated. Bone mineral content (BMC), bone area (BA) and bone mineral density (BMD) were measured at total body using Dual Energy X-ray Absorptiometry (Lunar DPX-PRO). Polymorphisms of the Fok1 locus of the vitamin D Receptor (VDR) gene were detected using SYBR Green quantitative polymerase chain reaction.

resultsThe prevalence of Fok1 polymorphism was 43.1% (Ff), 9.8% (ff) and 47.1% (FF). At baseline, FF genotype had significantly lower BMD as compared to ff and Ff genotype (p < 0.05). At baseline, majority of girls (82.4%) were hypocalcemic with low calcium intake. Post-supplementation, FF genotype had significantly lower bone mass as compared to ff and Ff genotype. Significant increase in BMC [Ff (17.9%); ff (18.1%); FF (17.4%)], and BMD [Ff (5.4 %); ff (6.3%); FF (4.8%)] was observed post supplementation (p value < 0.05), though percentage increase in BMC and BMD was similar for three Fok1 polymorphisms (p > 0.1).

conclusionsVDR gene polymorphism, as defined by Fok1 genotype had no positive influence on bone mass accrual in response to calcium supplementation.

Indexed as

Absorptiometry, PhotonAdolescentBone DensityCalciumChildCholecalciferolDietary SupplementsFemaleGenotypeHumansIndiaPolymorphism, GeneticReal-Time Polymerase Chain ReactionReceptors, CalcitriolCalciumCholecalciferolReceptors, CalcitriolVDR protein, humanBone mass accrualFok1GirlsIndianVitamin D receptor gene

Identifiers

PMID25972288
OpenAlexW1518396310

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.