ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Synapsin determines memory strength after punishment- and relief-learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
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- Effects of aversive conditioning on expression of physiological stress in honey bees (Apis mellifera).Neurobiology of learning and memory · 2021Article
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- Cell-to-Cell Communication in Learning and Memory: From Neuro- and Glio-Transmission to Information Exchange Mediated by Extracellular Vesicles.International journal of molecular sciences · 2019Review
- Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics.eLife · 2019Article
- Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion.Neural plasticity · 2019Article
- Reinforcement signaling of punishment versus relief in fruit flies.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Cyclic AMP-dependent plasticity underlies rapid changes in odor coding associated with reward learning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Associative Learning of Stimuli Paired and Unpaired With Reinforcement: Evaluating Evidence From Maggots, Flies, Bees, and Rats.Frontiers in psychology · 2018Article
- Requirement of NF-kappa B Activation in Different Mice Brain Areas during Long-Term Memory Consolidation in Two Contextual One-Trial Tasks with Opposing Valences.Frontiers in molecular neuroscience · 2017Article
- Independent natural genetic variation of punishment- versus relief-memory.Biology letters · 2016Article
- Sir2/Sirt1 Links Acute Inebriation to Presynaptic Changes and the Development of Alcohol Tolerance, Preference, and Reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation.Molecular & cellular proteomics : MCP · 2016Article
- Synapsin is required to "boost" memory strength for highly salient events.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Reversing Stimulus Timing in Visual Conditioning Leads to Memories with Opposite Valence in Drosophila.PloS one · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse life events can induce two kinds of memory with opposite valence, dependent on timing: "negative" memories for stimuli preceding them and "positive" memories for stimuli experienced at the moment of "relief." Such punishment memory and relief memory are found in insects, rats, and man. For example, fruit flies (Drosophila melanogaster) avoid an odor after odor-shock training ("forward conditioning" of the odor), whereas after shock-odor training ("backward conditioning" of the odor) they approach it. Do these timing-dependent associative processes share molecular determinants? We focus on the role of Synapsin, a conserved presynaptic phosphoprotein regulating the balance between the reserve pool and the readily releasable pool of synaptic vesicles. We find that a lack of Synapsin leaves task-relevant sensory and motor faculties unaffected. In contrast, both punishment memory and relief memory scores are reduced. These defects reflect a true lessening of associative memory strength, as distortions in nonassociative processing (e.g., susceptibility to handling, adaptation, habituation, sensitization), discrimination ability, and changes in the time course of coincidence detection can be ruled out as alternative explanations. Reductions in punishment- and relief-memory strength are also observed upon an RNAi-mediated knock-down of Synapsin, and are rescued both by acutely restoring Synapsin and by locally restoring it in the mushroom bodies of mutant flies. Thus, both punishment memory and relief memory require the Synapsin protein and in this sense share genetic and molecular determinants. We note that corresponding molecular commonalities between punishment memory and relief memory in humans would constrain pharmacological attempts to selectively interfere with excessive associative punishment memories, e.g., after traumatic experiences.
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