ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Visual Simulation Is Supported by Sequential Monitoring in the Lateral Prefrontal Cortex.Journal of cognitive neuroscience · 2026Article
- Dorsal raphe nucleus controls motivation-state transitions in monkeys.Science advances · 2025Article
- Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.Nature communications · 2025Article
- Neurons of Macaque Frontal Eye Field Signal Reward-Related Surprise.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Modulation of the p75NTR during Adolescent Alcohol Exposure Prevents Cholinergic Neuronal Atrophy and Associated Acetylcholine Activity and Behavioral Dysfunction.International journal of molecular sciences · 2024Article
- Basal Forebrain Cholinergic Neurons Have Specific Characteristics during the Perinatal Period.eNeuro · 2024Article
- An opponent striatal circuit for distributional reinforcement learning.bioRxiv : the preprint server for biology · 2024Article
- Studying the neural representations of uncertainty.Nature neuroscience · 2023Review
- Cholinergic Reinforcement Signaling Is Impaired by Amyloidosis Prior to Its Synaptic Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Rewarding-unrewarding prediction signals under a bivalent context in the primate lateral hypothalamus.Scientific reports · 2023Article
- Enhanced endogenous oxytocin signaling in the brain modulates neural responses to social misalignment and promotes conformity in humans: A multi-locus genetic profile approach.Psychoneuroendocrinology · 2022Article
- Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway.Progress in neurobiology · 2022Article
- Different types of uncertainty distinguished by monkey prefrontal neurons.Cerebral cortex communications · 2022Article
- A primate temporal cortex-zona incerta pathway for novelty seeking.Nature neuroscience · 2022Article
- Interactions between ventrolateral prefrontal and anterior cingulate cortex during learning and behavioural change.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- A prefrontal network integrates preferences for advance information about uncertain rewards and punishments.Neuron · 2021Article
- Contribution of the basal forebrain to corticocortical network interactions.Brain structure & function · 2021Article
- Common coding of expected value and value uncertainty memories in the prefrontal cortex and basal ganglia output.Science advances · 2021Article
- Excitatory-inhibitory tone shapes decision strategies in a hierarchical neural network model of multi-attribute choice.PLoS computational biology · 2021Article
- Social processing by the primate medial frontal cortex.International review of neurobiology · 2021Review
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Authors and funding
3 authors.
Funding
Abstract
It has been suggested that the basal forebrain (BF) exerts strong influences on the formation of memory and behavior. However, what information is used for the memory-behavior formation is unclear. We found that a population of neurons in the medial BF (medial septum and diagonal band of Broca) of macaque monkeys encodes a unique combination of information: reward uncertainty, expected reward value, anticipation of punishment, and unexpected reward and punishment. The results were obtained while the monkeys were expecting (often with uncertainty) a rewarding or punishing outcome during a Pavlovian procedure, or unexpectedly received an outcome outside the procedure. In vivo anterograde tracing using manganese-enhanced MRI suggested that the major recipient of these signals is the intermediate hippocampal formation. Based on these findings, we hypothesize that the medial BF identifies various contexts and outcomes that are critical for memory processing in the hippocampal formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.