ReviewPlacenta2015
Inflammation in maternal obesity and gestational diabetes mellitus.
Review in Placenta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 290 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
290 citing papers in PubMed, 8 syntheses or guidelines pooled it, 565 citations in OpenAlex.
- Early pregnancy biomarkers for gestational diabetes mellitus prediction: a systematic review and meta-analysis of routine laboratory, metabolic, and inflammatory markers.Frontiers in endocrinology · 2026Pooled it
- The association between the dietary inflammatory index during pregnancy and risk of gestational diabetes: a prospective cohort study and a meta-analysis.BMC endocrine disorders · 2025Pooled it
- Pooled it
- Lymphocyte Subsets and Cytokine Changes in Women With Gestational Diabetes Mellitus: A Systematic Review.Journal of diabetes research · 2025Pooled it
- Association of gastrointestinal microbiome and obesity with gestational diabetes mellitus-an updated globally based review of the high-quality literatures.Nutrition & diabetes · 2024Pooled it
- [Pathways and Mechanisms of Periodontitis Contributing to Adverse Pregnancy Outcomes].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Pooled it
- Pooled it
- Chemokines in Gestational Diabetes Mellitus.Frontiers in immunology · 2022Pooled it
- OLIDIAG Study: Extra Virgin Olive Oil Supplementation in the Diet of Women with Gestational Diabetes Mellitus-A Randomized Clinical Trial.Nutrients · 2026Trial
- Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Trial
- Supplementation with antioxidant micronutrients in pregnant women with obesity: a randomized controlled trial.International journal of obesity (2005) · 2024Trial
- Maternal AA/EPA Ratio and Triglycerides as Potential Biomarkers of Patients at Major Risk for Pharmacological Therapy in Gestational Diabetes.Nutrients · 2022Trial
- lncRNA PANDAR predicts adverse pregnancy outcomes and reflects hyperglycemia-associated cellular stress in gestational diabetes mellitus.Journal of endocrinological investigation · 2026Article
- Article
- Maternal obesity disrupts trophoblast differentiation and causes female-specific labyrinth defects in the mouse placenta.American journal of physiology. Cell physiology · 2026Article
- Association of first-trimester inflammatory markers with gestational diabetes mellitus subtypes and patterns: a cohort study.Journal of endocrinological investigation · 2026Article
- Article
- The impact of obesity and overweight on maternal and fetal health with conservative preconception interventions: a structured narrative review.Archives of gynecology and obstetrics · 2026Review
- Decreased Serum Salusin-β Levels Are Independently Associated with Gestational Diabetes Mellitus.Biomedicines · 2026Article
- Tissue-resident neutrophils serve homeostatic and immunological functions in embryos.Nature communications · 2026Article
230 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe prevalence of maternal obesity is rising rapidly worldwide and constitutes a major obstetric problem, increasing mortality and morbidity in both mother and offspring. Obese women are predisposed to pregnancy complications such as gestational diabetes mellitus (GDM), and children of obese mothers are more likely to develop cardiovascular and metabolic disease in later life. Maternal obesity and GDM may be associated with a state of chronic, low-grade inflammation termed "metainflammation", as opposed to an acute inflammatory response. This inflammatory environment may be one mechanism by which offspring of obese women are programmed to develop adult disorders.
methodsHerein we review the evidence that maternal obesity and GDM are associated with changes in the maternal, fetal and placental inflammatory profile.
resultsMaternal inflammation in obesity and GDM may not always be associated with fetal inflammation.
conclusionWe propose that the placenta 'senses' and adapts to the maternal inflammatory environment, and plays a central role as both a target and producer of inflammatory mediators. In this manner, maternal obesity and GDM may indirectly program the fetus for later disease by influencing placental function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.