Evidence map›Paper›PMID 25971980›Full record

ArticleReproductive health2015

Oral contraceptives and antibiotics. A cross-sectional study about patients' knowledge in general practice.

Kathryn Hoffmann, Aaron George, Lukas Heschl, Anna Katharina Leifheit, Manfred Maier

Open access · goldAbstract read
In one paragraph

Article in Reproductive health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. A review of diagnosis and treatment of acne in adult female patients.International journal of women's dermatology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Kathryn HoffmannDepartment of General Practice and Family Medicine, Centre for Public Health, Medical, University of Vienna, Kinderspitalgasse 15/I 1st floor, 1090, Vienna, Austria. kathryn.hoffmann@meduniwien.ac.at.
Aaron GeorgeDepartment of Community and Family Medicine, Duke Medical Center, 2301 Erwin Rd, Box 3886, Durham, 27705, USA, North Carolina. aaron.george@duke.edu.
Lukas HeschlDepartment of General Practice and Family Medicine, Centre for Public Health, Medical, University of Vienna, Kinderspitalgasse 15/I 1st floor, 1090, Vienna, Austria. heschlius@hotmail.com.
Anna Katharina LeifheitDepartment of General Practice and Family Medicine, Centre for Public Health, Medical, University of Vienna, Kinderspitalgasse 15/I 1st floor, 1090, Vienna, Austria. heschlius@hotmail.com.
Manfred MaierDepartment of General Practice and Family Medicine, Centre for Public Health, Medical, University of Vienna, Kinderspitalgasse 15/I 1st floor, 1090, Vienna, Austria. manfred.maier@meduniwien.ac.at.
Medical University of Vienna · ATDuke Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe evidence regarding oral contraceptives and its effectiveness with concomitant ingestion of antibiotics is conflicting. Until evidence becomes clearer, patients should be aware of this possible interaction. The aim of this study was to assess the knowledge and the source of information about this interaction in GP patients in Austria.

methodsWithin the framework of the APRES study, 20 Austrian GPs were purposefully selected from among a GP research network and were asked to recruit 200 patients each. The patient cohort was asked to complete a questionnaire. Subsequent analysis included descriptive statistics, statistical tests and logistic regression models.

findingsOverall, 3280 questionnaires could be used for analysis. Of these, 29.7 % (n = 974) of patients acknowledged an awareness of the interaction of antibiotics with OCPs. Women under the age of 46 years acknowledged this interaction in 52.3 % of cases. Positive associations for the belief in an existing interaction in women were identified with age (OR 2.2) and having read the package inserts (OR 1.6). Further, belief was recognized in males based on age (OR 2.5) and tertiary education (OR 2.0). The main source of information regarding antibiotics was the GP (55.9 %).

conclusionsLess than one-third of all participants and half of the women in the reproductive age acknowledged an interaction between antibiotics and OCPs. Since the GP is the main source of information, this finding depicts a large potential for knowledge transfer within the primary health care setting. A multifaceted strategy is needed at both the population and the GP level to improve awareness and to address these educational gaps.

Indexed as

General PracticeHealth Knowledge, Attitudes, PracticeHealth Services Needs and DemandAdultAgedAnti-Bacterial AgentsContraceptives, OralCross-Sectional StudiesDrug InteractionsFemaleHumansMaleMiddle AgedAnti-Bacterial AgentsContraceptives, Oral

Identifiers

PMID25971980
PMCPMC4438508
OpenAlexW2156874863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.