ArticleThe Journal of biological chemistry2015
Specific Activation of the Plant P-type Plasma Membrane H+-ATPase by Lysophospholipids Depends on the Autoinhibitory N- and C-terminal Domains.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Isolation and characterization of plant plasma membrane P-type HScientific reports · 2026Article
- Functional reconstitution of plant plasma membrane HScientific reports · 2025Article
- Article
- Anionic Phospholipids Stimulate the Proton Pumping Activity of the Plant Plasma Membrane P-Type HInternational journal of molecular sciences · 2023Article
- Drought and heat stress mediated activation of lipid signaling in plants: a critical review.Frontiers in plant science · 2023Review
- Comprehensive analysis of glycerolipid dynamics during tobacco pollen germination and pollen tube growth.Frontiers in plant science · 2022Article
- Sterol Extraction from Isolated Plant Plasma Membrane Vesicles Affects HBiomolecules · 2021Article
- MPK6 Kinase Regulates Plasma Membrane HInternational journal of molecular sciences · 2021Article
- Link between Lipid Second Messengers and Osmotic Stress in Plants.International journal of molecular sciences · 2021Review
- Involvement of plasma membrane HPlanta · 2021Article
- Integrative analyses of transcriptomics and metabolomics upon seed germination of foxtail millet in response to salinity.Scientific reports · 2020Article
- Patatin-Related Phospholipase pPLAIIIγ Involved in Osmotic and Salt Tolerance inPlants (Basel, Switzerland) · 2020Article
- Plasma membrane HNature communications · 2020Article
- Tenuazonic acid from Stemphylium loti inhibits the plant plasma membrane HThe New phytologist · 2020Article
- Roles of plasma membrane proton ATPases AHA2 and AHA7 in normal growth of roots and root hairs in Arabidopsis thaliana.Physiologia plantarum · 2019Article
- Structural mapping of fluorescently-tagged, functional nhTMEM16 scramblase in a lipid bilayer.The Journal of biological chemistry · 2018Article
- Isolation of native plasma membrane HFEBS open bio · 2018Article
- A bioassay-guided fractionation system to identify endogenous small molecules that activate plasma membrane H+-ATPase activity in Arabidopsis.Journal of experimental botany · 2017Article
- Metal Fluoride Inhibition of a P-type H+ Pump: STABILIZATION OF THE PHOSPHOENZYME INTERMEDIATE CONTRIBUTES TO POST-TRANSLATIONAL PUMP ACTIVATION.The Journal of biological chemistry · 2015Article
- Deficiencies in cluster-2 ALA lipid flippases result in salicylic acid-dependent growth reductions.Physiologia plantarumArticle
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10 authors at 2 institutions in 1 country.
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Abstract
Eukaryotic P-type plasma membrane H(+)-ATPases are primary active transport systems that are regulated at the post-translation level by cis-acting autoinhibitory domains, which can be relieved by protein kinase-mediated phosphorylation or binding of specific lipid species. Here we show that lysophospholipids specifically activate a plant plasma membrane H(+)-ATPase (Arabidopsis thaliana AHA2) by a mechanism that involves both cytoplasmic terminal domains of AHA2, whereas they have no effect on the fungal counterpart (Saccharomyces cerevisiae Pma1p). The activation was dependent on the glycerol backbone of the lysophospholipid and increased with acyl chain length, whereas the headgroup had little effect on activation. Activation of the plant pump by lysophospholipids did not involve the penultimate residue, Thr-947, which is known to be phosphorylated as part of a binding site for activating 14-3-3 protein, but was critically dependent on a single autoinhibitory residue (Leu-919) upstream of the C-terminal cytoplasmic domain in AHA2. A corresponding residue is absent in the fungal counterpart. These data indicate that plant plasma membrane H(+)-ATPases evolved as specific receptors for lysophospholipids and support the hypothesis that lysophospholipids are important plant signaling molecules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.