Evidence map›Paper›PMID 25971927›Full record

ReviewInternational journal of obesity (2005)2015

The role of short chain fatty acids in appetite regulation and energy homeostasis.

C S Byrne, E S Chambers, D J Morrison, G Frost

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 284 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 14 pooled it
27.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 14 syntheses or guidelines pooled it, 701 citations in OpenAlex.

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  2. Impacts of Yacon Syrup (Nutrients · 2025
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  14. A systematic review on the role of microbiota in the pathogenesis and treatment of eating disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2020
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224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

C S ByrneNutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Faculty of Medicine, Hammersmith Campus, Imperial College London, London, UK.
E S ChambersNutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Faculty of Medicine, Hammersmith Campus, Imperial College London, London, UK.
D J MorrisonStable Isotope Biochemistry Laboratory, Scottish Universities Environmental Research Centre, University of Glasgow, Glasgow, Scotland.
G FrostNutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Faculty of Medicine, Hammersmith Campus, Imperial College London, London, UK.
University of Glasgow · GB

Funding

Biotechnology and Biological Sciences Research Council BB/H004815/1Biotechnology and Biological Sciences Research Council BB/H004971/1Biotechnology and Biological Sciences Research Council BB/L004259/1Medical Research Council
6 · The paper itself

Abstract

Over the last 20 years there has been an increasing interest in the influence of the gastrointestinal tract on appetite regulation. Much of the focus has been on the neuronal and hormonal relationship between the gastrointestinal tract and the brain. There is now mounting evidence that the colonic microbiota and their metabolic activity have a significant role in energy homeostasis. The supply of substrate to the colonic microbiota has a major impact on the microbial population and the metabolites they produce, particularly short chain fatty acids (SCFAs). SCFAs are produced when non-digestible carbohydrates, namely dietary fibres and resistant starch, undergo fermentation by the colonic microbiota. Both the consumption of fermentable carbohydrates and the administration of SCFAs have been reported to result in a wide range of health benefits including improvements in body composition, glucose homeostasis, blood lipid profiles and reduced body weight and colon cancer risk. However, published studies tend to report the effects that fermentable carbohydrates and SCFAs have on specific tissues and metabolic processes, and fail to explain how these local effects translate into systemic effects and the mitigation of disease risk. Moreover, studies tend to investigate SCFAs collectively and neglect to report the effects associated with individual SCFAs. Here, we bring together the recent evidence and suggest an overarching model for the effects of SCFAs on one of their beneficial aspects: appetite regulation and energy homeostasis.

Indexed as

MicrobiotaAppetite RegulationDietary FiberEnergy MetabolismEvidence-Based MedicineFatty Acids, VolatileFermentationGastrointestinal TractHomeostasisHost-Pathogen InteractionsHumansIntestinal AbsorptionObesityDietary FiberFatty Acids, Volatile

Identifiers

PMID25971927
PMCPMC4564526
OpenAlexW281347911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.