ArticleInternational journal of obesity (2005)2015
Maternal obesity programs offspring non-alcoholic fatty liver disease through disruption of 24-h rhythms in mice.
Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Significant nocturnal wakefulness after sleep onset in metabolic dysfunction-associated steatotic liver disease.Frontiers in network physiology · 2024Article
- Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice.Scientific reports · 2023Article
- Non-alcoholic fatty liver disease and the impact of genetic, epigenetic and environmental factors in the offspring.World journal of gastroenterology · 2022Review
- Optimization of Analysis of Circadian Rest-Activity Rhythm Using Cosinor Analysis in Mice.Psychiatry investigation · 2022Article
- LncRNA MALAT1 Promotes PPARα/CD36-Mediated Hepatic Lipogenesis in Nonalcoholic Fatty Liver Disease by Modulating miR-206/ARNT Axis.Frontiers in bioengineering and biotechnology · 2022Article
- Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.Comprehensive Physiology · 2021Review
- Adverse Maternal Environment and Postweaning Western Diet Alter Hepatic CD36 Expression and Methylation Concurrently with Nonalcoholic Fatty Liver Disease in Mouse Offspring.The Journal of nutrition · 2021Article
- Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures.Aging and disease · 2021Review
- Maternal high-fat diet disrupted one-carbon metabolism in offspring, contributing to nonalcoholic fatty liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Developmental Programming of NAFLD by Parental Obesity.Hepatology communications · 2020Review
- Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation.Scientific reports · 2019Article
- Ethnic differences and heterogeneity in genetic and metabolic makeup contributing to nonalcoholic fatty liver disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
- "Gut Microbiota-Circadian Clock Axis" in Deciphering the Mechanism Linking Early-Life Nutritional Environment and Abnormal Glucose Metabolism.International journal of endocrinology · 2019Review
- Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation.The Journal of physiology · 2018Article
- Developmental origins of nonalcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease.American journal of physiology. Endocrinology and metabolism · 2018Review
- Maternal high-fat diet consumption induces sex-dependent alterations of the endocannabinoid system and redox homeostasis in liver of adult rat offspring.Scientific reports · 2018Article
- Maternal high-fat diet associated with altered gene expression, DNA methylation, and obesity risk in mouse offspring.PloS one · 2018Article
- Developmental Programming of Obesity and Liver Metabolism by Maternal Perinatal Nutrition Involves the Melanocortin System.Nutrients · 2017Article
- Conditional postnatal deletion of the neonatal murine hepatic circadian gene, Npas2, alters the gut microbiome following restricted feeding.American journal of obstetrics and gynecology · 2017Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMaternal obesity increases offspring propensity to metabolic dysfunctions and to non-alcoholic fatty liver disease (NAFLD), which may lead to cirrhosis or liver cancer. The circadian clock is a transcriptional/epigenetic molecular machinery synchronising physiological processes to coordinate energy utilisation within a 24-h light/dark period. Alterations in rhythmicity have profound effects on metabolic pathways, which we sought to investigate in offspring with programmed NAFLD.
methodsMice were fed a standard or an obesogenic diet (OD), before and throughout pregnancy, and during lactation. Offspring were weaned onto standard or an OD at 3 weeks postpartum and housed in 12:12 light/dark conditions. Biochemical and histological indicators of NAFLD and fibrosis, analysis of canonical clock genes with methylation status and locomotor activity were investigated at 6 months.
resultsWe show that maternal obesity interacts with an obesogenic post-weaning diet to promote the development of NAFLD with disruption of canonical metabolic rhythmicity gene expression in the liver. We demonstrate hypermethylation of BMAL-1 (brain and muscle Arnt like-1) and Per2 promoter regions and altered 24-h rhythmicity of hepatic pro-inflammatory and fibrogenic mediators.
conclusionsThese data implicate disordered circadian rhythms in NAFLD and suggest that disruption of this system during critical developmental periods may be responsible for the onset of chronic liver disease in adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.