ArticleEuropean journal of nutrition2016
Association between obesity and glomerular hyperfiltration: the confounding effect of smoking and sodium and protein intakes.
Article in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Protein intake and risk of urolithiasis and kidney diseases: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society.European journal of nutrition · 2023Pooled it
- A Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational Studies.Advances in nutrition (Bethesda, Md.) · 2018Pooled it
- Trial
- Effect of Acetazolamide on Obesity-Induced Glomerular Hyperfiltration: A Randomized Controlled Trial.PloS one · 2015Trial
- Integrating the new pharmacological standard of care with traditional nutritional interventions in non-dialysis CKD.Journal of nephrology · 2025Review
- Prediction of post-donation renal function using machine learning techniques and conventional regression models in living kidney donors.Journal of nephrology · 2024Article
- Measuring Albuminuria in Individuals With Obesity: Pitfalls of the Urinary Albumin-Creatinine Ratio.Kidney medicine · 2024Review
- The urine-to-plasma urea concentration ratio is associated with eGFR and eGFR decline over time in a population cohort.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Renal Dysfunction Phenotypes in Patients Undergoing Obesity Surgery.Biomolecules · 2023Article
- Design, recruitment, and baseline characteristics of the EMPA-KIDNEY trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Review
- Young Adults with Higher Salt Intake Have Inferior Hydration Status: A Cross-Sectional Study.Nutrients · 2022Article
- High concentrations of triglycerides are associated with diabetic kidney disease in new-onset type 2 diabetes in China: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study.Diabetes, obesity & metabolism · 2021Article
- Association of the ratio of visceral-to-subcutaneous fat volume with renal function among patients with primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Protein Intake and Human Health: Implications of Units of Protein Intake.Advances in nutrition (Bethesda, Md.) · 2021Article
- Cross-sectional associations between central and general adiposity with albuminuria: observations from 400,000 people in UK Biobank.International journal of obesity (2005) · 2020Article
- Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- High-normal albuminuria is strongly associated with incident chronic kidney disease in a nondiabetic population with normal range of albuminuria and normal kidney function.Clinical and experimental nephrology · 2020Article
- Article
- The potential for improving cardio-renal outcomes by sodium-glucose co-transporter-2 inhibition in people with chronic kidney disease: a rationale for the EMPA-KIDNEY study.Clinical kidney journal · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGlomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease (CKD), independently of classical risk factors. We explored the association of overweight and obesity with glomerular hyperfiltration in a large sample of the Swiss adult population, accounting for several confounders including dietary factors.
methodsData from a 2010 to 2012 cross-sectional population-based survey in Switzerland were used. Creatinine clearance (CrCl) was determined from 24-h urine collection; CrCl > 140 ml/min was used to define glomerular hyperfiltration. Participants were categorized into lean (<25 kg/m(2)), overweight (25-29.9 kg/m(2)) and obese (≥30 kg/m(2)) according to body mass index (BMI).
resultsA total of 1339 participants were included in the analysis [median (IQR) age 49.4 (34.3-63.5) years, 48.9 % men]. The prevalences of overweight and obesity were 32.2 and 14.2 %, respectively. Median CrCl was 102[84-121] ml/min in lean, 110 [87-136] ml/min in overweight and 124 [97-150] ml/min in obese participants (p < 0.001). The prevalence of glomerular hyperfiltration increased across BMI categories (10.4, 20.8 and 34.7 %, respectively; p < 0.001). This positive association remained significant after adjusting for age, sex, hypertension, diabetes, smoking and dietary factors (sodium and protein intakes): odds ratio [95 %CI] 2.39 [1.52-3.76] (p < 0.001) for overweight versus lean and 4.10[2.31-7.27] (p < 0.001) for obesity versus lean.
conclusionsBMI categories and glomerular hyperfiltration are positively associated, independently of other known CKD risk factors and dietary confounders, suggesting that glomerular hyperfiltration may represent an early renal phenotype in obesity. Our observations confirm the significant association of glomerular hyperfiltration with sodium and protein intakes and identify sodium intake as an important modifying factor of the association between hyperfiltration and obesity.
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Registered trials
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