ArticleProceedings of the National Academy of Sciences of the United States of America2015
Postmitotic regulation of sensory area patterning in the mammalian neocortex by Lhx2.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- LHX2: a transcription factor in development, homeostasis, repair, and disease.Frontiers in cell and developmental biology · 2026Review
- Neocortical neurogenesis: a proneural gene perspective.The FEBS journal · 2025Review
- Analysis of downstream targets of PAX6 and LHX2, fundamental regulators of the developing mammalian neocortex.Journal of biosciences · 2025Article
- Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2.PLoS genetics · 2023Article
- Identification of a Developmental Switch in Information Transfer between Whisker S1 and S2 Cortex in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Transcriptional and epigenetic regulation of temporal patterning in neural progenitors.Developmental biology · 2022Review
- An Early Cortical Progenitor-Specific Mechanism Regulates Thalamocortical Innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Mutually Repulsive EphA7-EfnA5 Organize Region-to-Region Corticopontine Projection by Inhibiting Collateral Extension.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Structural and Functional Aspects of the Neurodevelopmental GeneFrontiers in molecular neuroscience · 2021Review
- How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Brain organoids: advances, applications and challenges.Development (Cambridge, England) · 2019Review
- Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Distal regulatory elements identified by methylation and hydroxymethylation haplotype blocks from mouse brain.Epigenetics & chromatin · 2018Article
- How Areal Specification Shapes the Local and Interareal Circuits in a Macaque Model of Congenital Blindness.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Prenatal Ethanol Exposure and Neocortical Development: A Transgenerational Model of FASD.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice andThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Prenatal thalamic waves regulate cortical area size prior to sensory processing.Nature communications · 2017Article
- LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Generation and analysis of an improved Foxg1-IRES-Cre driver mouse line.Developmental biology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Current knowledge suggests that cortical sensory area identity is controlled by transcription factors (TFs) that specify area features in progenitor cells and subsequently their progeny in a one-step process. However, how neurons acquire and maintain these features is unclear. We have used conditional inactivation restricted to postmitotic cortical neurons in mice to investigate the role of the TF LIM homeobox 2 (Lhx2) in this process and report that in conditional mutant cortices area patterning is normal in progenitors but strongly affected in cortical plate (CP) neurons. We show that Lhx2 controls neocortical area patterning by regulating downstream genetic and epigenetic regulators that drive the acquisition of molecular properties in CP neurons. Our results question a strict hierarchy in which progenitors dominate area identity, suggesting a novel and more comprehensive two-step model of area patterning: In progenitors, patterning TFs prespecify sensory area blueprints. Sequentially, sustained function of alignment TFs, including Lhx2, is essential to maintain and to translate the blueprints into functional sensory area properties in cortical neurons postmitotically. Our results reemphasize critical roles for Lhx2 that acts as one of the terminal selector genes in controlling principal properties of neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.